Case studies using the YNA database. (a) A combined search of H3K4ac and H3K4me3 in the promoter region in the genome-wide gene miner of the YNA, which leads to the retrieval of 1516 genes that match the query criteria. The retrieved genes were further analyzed using the biological significance analyzer, which displays the enrichments of the histone modifications (b), the enrichments of the regulatory protein binding occupancy (c), the transcription rate in 5 groups (d), and the enrichments of the functional categories (e) of the retrieved genes. (f) Another search of H4ac enriched in the promoter region, which results in the retrieval of 3549 genes that match the query criteria. (g - j) The biological significance analyzer analyzes these retrieved genes and provides the enrichment analyses in the four aspects.