Figure 4

The G protein-coupled receptor pathway is involved in transmembrane signaling and diverse physiological functions including hormone signaling, regulation of cell contraction, cell migration, growth and differentiation. Members of the G protein-coupled receptors, G protein alpha q, G protein alpha i/o, and PKA are upregulated (red) whereas members of MAPK phosphatases (MKP), phosphodiesterases (PDE) and adenylate cyclases (AC) are downregulated (green) in BRAF^wt compared to BRAF^mut PTCs.