Table 6 Annotation enrichment of genes targeted by H. s. d. and H. s. n. miRNAs expressed in neural tissues, based on DAVID 6.7 [24]; BrainSpan gene list (16767 genes expressed in human brain) used as a background.
SP_PIR_KEYWORDS category * | # of genes | Corrected p-value | |
|---|---|---|---|
| Â | Â | Bonferroni | Benjamini |
Target genes of unique H. s. d. miRNAs | |||
transport | 176 | 0.04072 | 0.04072 |
Target genes of unique H. s. n. miRNAs | |||
- | |||
Target genes of H. s. d. miRNAs having substitutions shared with known human polymorphisms | |||
phosphoprotein | 1018 | 1.56E-22 | 1.56E-22 |
alternative splicing | 1013 | 4.70E-19 | 2.35E-19 |
transcription | 298 | 3.72E-06 | 1.24E-06 |
transcription regulation | 292 | 3.86E-06 | 9.64E-07 |
metal-binding | 403 | 2.56E-05 | 5.13E-06 |
chromosomal rearrangement | 63 | 7.14E-05 | 1.19E-05 |
zinc | 302 | 8.79E-05 | 1.26E-05 |
activator | 98 | 2.27E-04 | 2.84E-05 |
cell junction | 76 | 0.00179 | 1.99E-04 |
zinc-finger | 231 | 0.00455 | 4.56E-04 |
synapse | 45 | 0.01100 | 0.00100 |
DNA-binding | 246 | 0.02287 | 0.00193 |
Target genes of H. s. n. miRNAs having substitutions shared with known human polymorphisms | |||
phosphoprotein | 565 | 3.62E-04 | 3.62E-04 |
alternative splicing | 574 | 0.00226 | 0.00113 |
developmental protein | 84 | 0.00665 | 0.00222 |
cytoplasm | 279 | 0.00715 | 0.00179 |