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Table 6 Annotation enrichment of genes targeted by H. s. d. and H. s. n. miRNAs expressed in neural tissues, based on DAVID 6.7 [24]; BrainSpan gene list (16767 genes expressed in human brain) used as a background.

From: The evolution of Homo sapiens denisova and Homo sapiens neanderthalensis miRNA targeting genes in the prenatal and postnatal brain

SP_PIR_KEYWORDS category * # of genes Corrected p-value
   Bonferroni Benjamini
Target genes of unique H. s. d. miRNAs
transport 176 0.04072 0.04072
Target genes of unique H. s. n. miRNAs
-
Target genes of H. s. d. miRNAs having substitutions shared with known human polymorphisms
phosphoprotein 1018 1.56E-22 1.56E-22
alternative splicing 1013 4.70E-19 2.35E-19
transcription 298 3.72E-06 1.24E-06
transcription regulation 292 3.86E-06 9.64E-07
metal-binding 403 2.56E-05 5.13E-06
chromosomal rearrangement 63 7.14E-05 1.19E-05
zinc 302 8.79E-05 1.26E-05
activator 98 2.27E-04 2.84E-05
cell junction 76 0.00179 1.99E-04
zinc-finger 231 0.00455 4.56E-04
synapse 45 0.01100 0.00100
DNA-binding 246 0.02287 0.00193
Target genes of H. s. n. miRNAs having substitutions shared with known human polymorphisms
phosphoprotein 565 3.62E-04 3.62E-04
alternative splicing 574 0.00226 0.00113
developmental protein 84 0.00665 0.00222
cytoplasm 279 0.00715 0.00179
  1. * bold - common between target genes of H. s. n. and H. s. d. miRNAs having substitutions shared with known human polymorphisms.