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Figure 1 | BMC Genomics

Figure 1

From: Obesity-related known and candidate SNP markers can significantly change affinity of TATA-binding protein for human gene promoters

Figure 1

Measurement of the kinetics of TBP binding to the oligodeoxyribonucleotide atcgggccgctataagTggggcgggc corresponding to rs34104384 (minor allele). A: Dependences of reaction rates on ODN concentration. B: Electropherograms from which these curves were derived. TBP concentration was 0.3 nM in all experiments; the concentrations of ODN were as indicated in the TBP/TATA-associated isotherms. The ka and kd values were calculated from the electropherograms using the GraphPad Prism 5 software (http://graphpad-prism.software.informer.com/5.01).

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BMC Genomics

ISSN: 1471-2164

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