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Table 4 Function analysis of 204 down-regulated target genes of UPmiRs and 295 up-regulated target genes of DNmiRs in IPA "Canonical Pathways".

From: Integrated analyses to reconstruct microRNA-mediated regulatory networks in mouse liver using high-throughput profiling

Ingenuity Canonical Pathways UPmiRs DNmiRs
  pvalue Count pvalue Count
Superpathway of Cholesterol Biosynthesis 8.51E-06 5   
Glycogen Biosynthesis II (from UDP-D-Glucose) 1.10E-03 2   
Pyrimidine Deoxyribonucleotides De Novo Biosynthesis I 2.09E-02 2   
Regulation of the Epithelial-Mesenchymal Transition Pathway 4.57E-02 5 7.76E-02 6
Leukocyte Extravasation Signaling 5.50E-02 5 4.17E-03 9
Integrin Signaling 5.50E-02 5 7.59E-05 12
PDGF Signaling 1.98E-01 2 2.51E-04 7
CXCR4 Signaling 2.12E-01 3 3.02E-03 8
PAK Signaling 2.29E-01 3 2.57E-03 6
p53 Signaling 2.64E-01 3 4.27E-03 6
IGF-1 Signaling 2.64E-01 3 2.19E-05 9
p70S6K Signaling 3.54E-01 3 1.20E-02 6
RhoA Signaling 3.54E-01 3 2.95E-03 7
Axonal Guidance Signaling 4.68E-01 5 5.50E-04 17
Molecular Mechanisms of Cancer 5.28E-01 4 2.14E-03 14
NRF2-mediated Oxidative Stress Response 5.42E-01 2 1.86E-03 9
STAT3 Pathway 5.42E-01 1 1.78E-04 7
TGF-P Signaling 5.98E-01 1 7.08E-05 8
Glioma Signaling 6.35E-01 1 8.32E-04 7
Actin Cytoskeleton Signaling 6.76E-03 9
Hepatic Fibrosis/Hepatic Stellate Cell Activation 2.82E-04 11
Protein Kinase A Signaling 9.33E-04 15
ERK/MAPK Signaling 8.91E-03 8
PTEN Signaling 6.03E-04 8
NF-κB Signaling 5.37E-03 8
Regulation of Actin-based Motility by Rho 2.45E-03 6
Cell Cycle: G2/M DNA Damage Checkpoint Regulation 8.13E-03 4
Total number of UPmiR-targets: 29
Total number of DNmiR-targets: 76