Table 2 Top 20 candidate genes for epileptic encephalopathies.
From: Pinpointing disease genes through phenomic and genomic data fusion
Rank | Chromosome | Gene | p-value | q-value | Functional |
|---|---|---|---|---|---|
1 | 2 | SCN2A | 1.03E-06 | 0.000118 | Yes |
2 | 5 | GABRA1 | 1.38E-06 | 0.000118 | Yes |
3 | 2 | SCN1A | 2.04E-06 | 0.000118 | Yes |
4 | 15 | GABRB3 | 6.37E-06 | 0.000277 | Yes |
5 | 9 | KCNT1 | 1.03E-05 | 0.000359 | Yes |
6 | 20 | KCNQ2 | 1.46E-05 | 0.000423 | Yes |
7 | 4 | GABRB1 | 3.07E-05 | 0.000702 | − |
8 | 8 | KCNQ3 | 3.23E-05 | 0.000702 | Yes |
9 | 12 | SCN8A | 6.59E-05 | 0.001153 | Yes |
10 | 9 | STXBP1 | 6.62E-05 | 0.001153 | Yes |
11 | X | ALG13 | 0.000256 | 0.004053 | Yes |
12 | X | CDKL5 | 0.005170 | 0.074969 | Yes |
13 | 20 | KCNB1 | 0.008351 | 0.111775 | − |
14 | 10 | ANK3 | 0.010374 | 0.128932 | Yes |
15 | 11 | FAM86C1 | 0.012323 | 0.138576 | − |
16 | 5 | GPR98 | 0.013428 | 0.138576 | − |
17 | 9 | GRIN1 | 0.013539 | 0.138576 | Yes |
18 | 1 | NFASC | 0.015651 | 0.151292 | − |
19 | 12 | CUX2 | 0.016939 | 0.155127 | − |
20 | 12 | GRIN2B | 0.018004 | 0.156637 | Yes |