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Table 2 The metastasis-associated HOTAIR was annotated with metastasis-related GO and pathway terms by LncRNA2Function.

From: LncRNA2Function: a comprehensive resource for functional investigation of human lncRNAs based on RNA-seq data

Database Functional term Background frequency Sample frequency P-value Corrected P-value
GO Locomotion 1022/20447 14/74 1.53E-05 0.003417
GO Cell migration 603/20447 10/74 6.07E-05 0.010887
GO Cell adhesion 790/20447 11/74 1.21E-04 0.020655
GO Biological adhesion 792/20447 11/74 1.24E-04 0.020663
GO Cell motility 664/20447 10/74 1.34E-04 0.021695
GO Positive regulation of cell-cell adhesion 33/20447 3/74 2.30E-04 0.032376
PID Beta1 integrin cell surface interactions 75/20447 7/74 9.92E-09 2.22E-06
Reactome Extracellular matrix organization 102/20447 7/74 8.54E-08 9.57E-06
KEGG ECM-receptor interaction 110/20447 7/74 1.44E-07 1.07E-05
INOH Integrin 141/20447 7/74 7.82E-07 4.01E-05
Wikipathways Focal Adhesion 203/20447 7/74 8.79E-06 2.46E-04
KEGG Focal adhesion 219/20447 7/74 1.44E-05 3.58E-04
PID Beta3 integrin cell surface interactions 47/20447 4/74 2.51E-05 5.61E-04
PID Syndecan-1-mediated signaling events 50/20447 4/74 3.21E-05 6.53E-04
PID Integrin cell surface interactions 58/20447 4/74 5.78E-05 0.001079
PID Integrins in angiogenesis 73/20447 4/74 1.42E-04 0.002454
Reactome Integrin cell surface interactions 88/20447 4/74 2.93E-04 0.004373
KEGG PI3K-Akt signaling pathway 361/20447 7/74 3.29E-04 0.004606
Reactome Cell surface interactions at the vascular wall 104/20447 4/74 5.53E-04 0.006566
Reactome Signaling by PDGF 187/20447 5/74 5.86E-04 0.006566
Reactome NCAM1 interactions 45/20447 3/74 5.79E-04 0.006566
Reactome NCAM signaling for neurite out-growth 72/20447 3/74 0.002268 0.023101
Reactome Platelet Adhesion to exposed collagen 22/20447 2/74 0.002848 0.025533
PID VEGFR3 signaling in lymphatic endothelium 25/20447 2/74 0.003673 0.031645
Reactome Basigin interactions 26/20447 2/74 0.003969 0.032935
KEGG TGF-beta signaling pathway 92/20447 3/74 0.004537 0.036298
PID Wnt signaling network 29/20447 2/74 0.004924 0.038039
Reactome Degradation of the extracellular matrix 32/20447 2/74 0.005974 0.043169
Reactome Activation of Matrix Metalloproteinases 32/20447 2/74 0.005974 0.043169
PID Alpha4 beta1 integrin signaling events 34/20447 2/74 0.006725 0.046835