Table 2 The metastasis-associated HOTAIR was annotated with metastasis-related GO and pathway terms by LncRNA2Function.

GO

Locomotion

1022/20447

14/74

1.53E-05

0.003417

GO

Cell migration

603/20447

10/74

6.07E-05

0.010887

GO

Cell adhesion

790/20447

11/74

1.21E-04

0.020655

GO

Biological adhesion

792/20447

11/74

1.24E-04

0.020663

GO

Cell motility

664/20447

10/74

1.34E-04

0.021695

GO

Positive regulation of cell-cell adhesion

33/20447

3/74

2.30E-04

0.032376

PID

Beta1 integrin cell surface interactions

75/20447

7/74

9.92E-09

2.22E-06

Reactome

Extracellular matrix organization

102/20447

7/74

8.54E-08

9.57E-06

KEGG

ECM-receptor interaction

110/20447

7/74

1.44E-07

1.07E-05

INOH

Integrin

141/20447

7/74

7.82E-07

4.01E-05

Wikipathways

Focal Adhesion

203/20447

7/74

8.79E-06

2.46E-04

KEGG

Focal adhesion

219/20447

7/74

1.44E-05

3.58E-04

PID

Beta3 integrin cell surface interactions

47/20447

4/74

2.51E-05

5.61E-04

PID

Syndecan-1-mediated signaling events

50/20447

4/74

3.21E-05

6.53E-04

PID

Integrin cell surface interactions

58/20447

4/74

5.78E-05

0.001079

PID

Integrins in angiogenesis

73/20447

4/74

1.42E-04

0.002454

Reactome

Integrin cell surface interactions

88/20447

4/74

2.93E-04

0.004373

KEGG

PI3K-Akt signaling pathway

361/20447

7/74

3.29E-04

0.004606

Reactome

Cell surface interactions at the vascular wall

104/20447

4/74

5.53E-04

0.006566

Reactome

Signaling by PDGF

187/20447

5/74

5.86E-04

0.006566

Reactome

NCAM1 interactions

45/20447

3/74

5.79E-04

0.006566

Reactome

NCAM signaling for neurite out-growth

72/20447

3/74

0.002268

0.023101

Reactome

Platelet Adhesion to exposed collagen

22/20447

2/74

0.002848

0.025533

PID

VEGFR3 signaling in lymphatic endothelium

25/20447

2/74

0.003673

0.031645

Reactome

Basigin interactions

26/20447

2/74

0.003969

0.032935

KEGG

TGF-beta signaling pathway

92/20447

3/74

0.004537

0.036298

PID

Wnt signaling network

29/20447

2/74

0.004924

0.038039

Reactome

Degradation of the extracellular matrix

32/20447

2/74

0.005974

0.043169

Reactome

Activation of Matrix Metalloproteinases

32/20447

2/74

0.005974

0.043169

PID

Alpha4 beta1 integrin signaling events

34/20447

2/74

0.006725

0.046835