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Table 4 The top 20 pathways assigned to AIDS-related lncRNA HCP5 by our LncRNA2Function.

From: LncRNA2Function: a comprehensive resource for functional investigation of human lncRNAs based on RNA-seq data

Pahtway
database
Pahtway name Background frequency Sample frequency P-value Corrected P-value
Reactome Immune System 1177/20447 98/458 1.66E-30 2.14E-27
KEGG Natural killer cell mediated cytotoxicity 219/20447 38/458 6.00E-23 3.87E-20
PID Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 104/20447 28/458 1.06E-22 4.54E-20
Reactome Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 202/20447 35/458 3.36E-21 1.08E-18
Reactome Adaptive Immune System 772/20447 66/458 4.68E-21 1.21E-18
NetPath TCR 252/20447 36/458 6.84E-19 1.47E-16
KEGG Chemokine signaling pathway 195/20447 30/458 7.56E-17 1.39E-14
PID Generation of second messenger molecules 15/20447 11/458 7.96E-16 1.28E-13
KEGG Osteoclast differentiation 174/20447 27/458 2.20E-15 3.16E-13
PID TCR signaling in naive CD4+ T cells 80/20447 19/458 1.03E-14 1.32E-12
PID TCR signaling in naive CD8+ T cells 63/20447 17/458 2.63E-14 3.09E-12
PID IL12-mediated signaling events 81/20447 18/458 1.80E-13 1.94E-11
KEGG Cytokine-cytokine receptor interaction 291/20447 31/458 6.97E-13 6.42E-11
Reactome Innate Immune System 542/20447 43/458 6.96E-13 6.42E-11
KEGG Hematopoietic cell lineage 114/20447 20/458 9.26E-13 7.97E-11
KEGG T cell receptor signaling pathway 116/20447 20/458 1.30E-12 1.05E-10
Reactome Cell surface interactions at the vascular wall 104/20447 19/458 1.62E-12 1.23E-10
PID Cell surface interactions at the vascular wall 42/20447 13/458 4.26E-12 3.06E-10
Reactome Class A/1 (Rhodopsin-like receptors) 319/20447 31/458 7.85E-12 5.33E-10
PID Fc-epsilon receptor I signaling in mast cells 64/20447 15/458 8.34E-12 5.38E-10