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Table 5 Top 20 pathways enriched in protein-coding genes that are co-expressed with the liver-related lncRNA HULC.

From: LncRNA2Function: a comprehensive resource for functional investigation of human lncRNAs based on RNA-seq data

Pahtway
database
Pahtway name Background frequency Sample frequency P-value Corrected P-value
Reactome Metabolism 1394/20447 128/390 6.17E-54 6.23E-51
KEGG Metabolic pathways 1256/20447 109/390 7.95E-43 4.01E-40
KEGG Retinol metabolism 69/20447 29/390 5.66E-32 1.91E-29
KEGG Complement and coagulation cascades 87/20447 30/390 6.18E-30 1.56E-27
EHMN Androgen and estrogen biosynthesis and metabolism 90/20447 30/390 2.02E-29 4.07E-27
Reactome Biological oxidations 151/20447 36/390 2.71E-29 4.55E-27
KEGG Drug metabolism - cytochrome P450 76/20447 28/390 5.84E-29 8.41E-27
KEGG Metabolism of xenobiotics by cytochrome P450 87/20447 29/390 1.78E-28 2.24E-26
KEGG Chemical carcinogenesis 86/20447 28/390 3.33E-27 3.74E-25
EHMN Tyrosine metabolism 113/20447 30/390 4.29E-26 4.33E-24
EHMN Xenobiotics metabolism 54/20447 23/390 9.33E-26 8.56E-24
Reactome Metabolism of amino acids and derivatives 159/20447 32/390 1.09E-23 9.20E-22
Wikipathways metapathway biotransformation 190/20447 34/390 2.43E-23 1.88E-21
EHMN Linoleate metabolism 75/20447 24/390 2.81E-23 2.03E-21
Wikipathways cytochrome P450 68/20447 23/390 5.40E-23 3.63E-21
Wikipathways Complement and Coagulation Cascades 60/20447 22/390 5.97E-23 3.77E-21
EHMN Leukotriene metabolism 102/20447 26/390 2.87E-22 1.70E-20
Reactome Phase 1 - Functionalization of compounds 74/20447 23/390 5.01E-22 2.81E-20
KEGG Drug metabolism - other enzymes 53/20447 20/390 2.85E-21 1.51E-19
Reactome Xenobiotics 15/20447 13/390 3.68E-21 1.86E-19