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Table 2 Top 20 hub genes of the optimal ceRNA network.

From: Parameter optimization for constructing competing endogenous RNA regulatory network in glioblastoma multiforme and other cancers

Hub genes No. of first-order neighbors Percentage of total optimal ceRNA pairs Entrez gene name Typea Disease/Functiona
CDS2 1480 0.269% CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 enzyme  
PARVA 1470 0.267% parvin, alpha other cancer; cell death and survival
SLC1A2 1466 0.266% solute carrier family 1 (glial high affinity glutamate transporter), member 2 transporter neurological disease; hereditary disorder
NFIB 1435 0.260% nuclear factor I/B transcription regulator  
SSR1 1421 0.258% signal sequence receptor, alpha other  
GTF2H5 1407 0.255% general transcription factor IIH, polypeptide 5 other neurological disease; hereditary disorder
SAR1B 1398 0.254% SAR1 homolog B (S. cerevisiae) enzyme hereditary disorder
GSK3B 1392 0.253% glycogen synthase kinase 3 beta kinase cancer; cell death and survival; neurological disease; hereditary disorder
HEG1 1390 0.252% heart development protein with EGF-like domains 1 other cancer
ZNF148 1390 0.252% zinc finger protein 148 transcription regulator cell death and survival
EIF5 1387 0.252% eukaryotic translation initiation factor 5 translation regulator cancer
SMAD4 1382 0.251% SMAD family member 4 transcription regulator cancer; cell death and survival; prognosis biomarker; neurological disease; hereditary disorder
TCF4 1374 0.249% transcription factor 4 transcription regulator cell death and survival; neurological disease; hereditary disorder
QKI 1366 0.248% QKI, KH domain containing, RNA binding other cancer; neurological disease; hereditary disorder
LSAMP 1364 0.247% limbic system-associated membrane protein other  
ATXN1 1354 0.246% ataxin 1 transcription regulator cancer; cell death and survival; neurological disease; hereditary disorder
DCP2 1354 0.246% decapping mRNA 2 enzyme  
PSD3 1346 0.244% pleckstrin and Sec7 domain containing 3 other cancer; neurological disease
SLC38A1 1340 0.243% solute carrier family 38, member 1 transporter  
VAPB 1340 0.243% VAMP (vesicle-associated membrane protein)- associated protein B and C other cell death and survival; neurological disease; hereditary disorder
  1. a Annotations were obtained from Ingenuity Pathway Analysis (Qiagen Inc.).