Table 2 Top 20 hub genes of the optimal ceRNA network.
Hub genes | No. of first-order neighbors | Percentage of total optimal ceRNA pairs | Entrez gene name | Typea | Disease/Functiona |
|---|---|---|---|---|---|
CDS2 | 1480 | 0.269% | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 | enzyme | Â |
PARVA | 1470 | 0.267% | parvin, alpha | other | cancer; cell death and survival |
SLC1A2 | 1466 | 0.266% | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | transporter | neurological disease; hereditary disorder |
NFIB | 1435 | 0.260% | nuclear factor I/B | transcription regulator | Â |
SSR1 | 1421 | 0.258% | signal sequence receptor, alpha | other | Â |
GTF2H5 | 1407 | 0.255% | general transcription factor IIH, polypeptide 5 | other | neurological disease; hereditary disorder |
SAR1B | 1398 | 0.254% | SAR1 homolog B (S. cerevisiae) | enzyme | hereditary disorder |
GSK3B | 1392 | 0.253% | glycogen synthase kinase 3 beta | kinase | cancer; cell death and survival; neurological disease; hereditary disorder |
HEG1 | 1390 | 0.252% | heart development protein with EGF-like domains 1 | other | cancer |
ZNF148 | 1390 | 0.252% | zinc finger protein 148 | transcription regulator | cell death and survival |
EIF5 | 1387 | 0.252% | eukaryotic translation initiation factor 5 | translation regulator | cancer |
SMAD4 | 1382 | 0.251% | SMAD family member 4 | transcription regulator | cancer; cell death and survival; prognosis biomarker; neurological disease; hereditary disorder |
TCF4 | 1374 | 0.249% | transcription factor 4 | transcription regulator | cell death and survival; neurological disease; hereditary disorder |
QKI | 1366 | 0.248% | QKI, KH domain containing, RNA binding | other | cancer; neurological disease; hereditary disorder |
LSAMP | 1364 | 0.247% | limbic system-associated membrane protein | other | Â |
ATXN1 | 1354 | 0.246% | ataxin 1 | transcription regulator | cancer; cell death and survival; neurological disease; hereditary disorder |
DCP2 | 1354 | 0.246% | decapping mRNA 2 | enzyme | Â |
PSD3 | 1346 | 0.244% | pleckstrin and Sec7 domain containing 3 | other | cancer; neurological disease |
SLC38A1 | 1340 | 0.243% | solute carrier family 38, member 1 | transporter | Â |
VAPB | 1340 | 0.243% | VAMP (vesicle-associated membrane protein)- associated protein B and C | other | cell death and survival; neurological disease; hereditary disorder |