Figure 2
From: HEPeak: an HMM-based exome peak-finding package for RNA epigenome sequencing data
Illustration of the proposed Hidden Markov model. A. The graphical model of the proposed hidden Markov model. B. An illustration of the advantage of the proposed HMM. The region marked by a black bracket would be missed by a non-HMM based algorithm such as exomePeak because the reads do not show enrichment in IP. However, this region is likely part of the peak because it is located in the middle of consecutively enriched regions.