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Table 5 ECemble predicted enzymes from reviewed human proteome.

From: Application of a hierarchical enzyme classification method reveals the role of gut microbiome in human metabolism

Gene Name Accession $UniProt Annotation New ECemble Prediction EC Description of
Enzyme Function
DHRS7 Q9Y394 1.1.-.- 1.1.1.n4* (-)-trans-carveol dehydrogenase
GFOD1 Q9NXC2 1.-.-.- 1.1.1.n6* D-chiro-inositol 3-dehydrogenase
FOXRED1 Q96CU9 1.-.-.- 1.1.5.4* Malate dehydrogenase (quinone)
ALOX12B O75342 1.13.11.- 1.13.11.12* Linoleate 13S-lipoxygenase
ALDH8A1 Q9H2A2 1.2.1.- 1.2.1.16* Succinate-semialdehyde dehydrogenase (NAD(P)(+))
SCCPDH Q8NBX0 1.-.-.- 1.5.1.10* Saccharopine dehydrogenase (NADP(+), L-glutamate-forming)
TFB1M Q9UNQ2 2.1.1.- 2.1.1.182* 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase
METTL15 A6NJ78 2.1.1.- 2.1.1.199* 16S rRNA (cytosine(1402)-N(4))-methyltransferase
METTL15P1 P0C7V9 2.1.1.- 2.1.1.199* 16S rRNA (cytosine(1402)-N(4))-methyltransferase
PYROXD2 Q8N2H3 1.-.-.- 2.1.1.74* (FADH(2)-oxidizing)
GOT1L1 Q8NHS2 2.6.1.- 2.6.1.9* Histidinol-phosphate transaminase
FGGY Q96C11 2.7.1.- 2.7.1.16* Ribulokinase
ISPD A4D126 2.7.7.- 2.7.7.60* 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
GDPD3 Q7L5L3 3.1.-.- 3.1.4.46* Glycerophosphodiester phosphodiesterase
TLL1 O43897 3.4.24.- 3.4.24.21* Astacin
TASP1 Q9H6P5 3.4.25.- 3.4.25.2* HslU--HslV peptidase
ADAL Q6DHV7 3.5.4.- 3.5.4.2* Adenine deaminase
IREB2 P48200 None 4.2.1.33* 3-isopropylmalate dehydratase
TYRP1 P17643 1.14.18.- 1.14.11.13** Gibberellin 2-beta-dioxygenase
HSD11B2 P80365 1.1.1.- 1.3.1.9** Enoyl-[acyl-carrier-protein] reductase (NADH)
NDOR1 Q9UHB4 1.6.-.- 1.8.1.2** Sulfite reductase (NADPH)
ENDOV Q8N8Q3 3.1.26.- 3.1.21.7** Deoxyribonuclease V
ENPP5 Q9UJA9 3.1.-.- 3.6.1.27** Undecaprenyl-diphosphate phosphatase
MPPED2 Q15777 3.1.-.- 3.6.1.41** Bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
THNSL2 Q86YJ6 4.2.3.- 4.2.1.20** Tryptophan synthase
ALOXE3 Q9BYJ1 5.4.4.- 1.13.11.12*** Linoleate 13S-lipoxygenase
ABHD2 P08910 3.1.1.- 2.3.1.31*** Homoserine O-acetyltransferase
ABHD1 Q96SE0 3.1.1.- 2.3.1.31*** Homoserine O-acetyltransferase
ABHD3 Q8WU67 3.1.1.- 2.3.1.84*** Alcohol O-acetyltransferase
SDR42E1 Q8WUS8 1.1.1.- 5.1.3.20*** ADP-glyceromanno-heptose 6-epimerase
  1. $Current annotation is based on UniProt database
  2. n Preliminary EC numbers include an 'n' as part of the fourth digit in ENZYME database
  3. * Good predictions that complement the current annotations
  4. ** Predictions that differ from the current annotations only at the subclass level
  5. *** Predictions that differ from the current annotations at the class level