Systems analysis of gene ontology and biological pathways involved in post-myocardial infarction responses

BMC Genomics

Table 2 Pathways and GOBP in the MI functional pathway-process network.

GOBP names	F	C	A	E	P	I	H
activation of plasma proteins involved in acute inflammatory response		√
acute inflammatory response		√
blood coagulation	√	√	√	√		√	√
blood coagulation, extrinsic pathway			√	√
coagulation	√	√	√	√		√	√
complement activation		√
developmental growth	√				√
fibrinolysis	√				√
growth	√				√
hemostasis	√	√	√	√		√	√
negative regulation of blood coagulation	√	√	√		√	√
negative regulation of coagulation	√	√	√		√	√
negative regulation of multicellular organismal process					√
platelet activation	√		√	√
positive regulation of blood coagulation	√		√	√	√
positive regulation of calcium ion transport	√			√
positive regulation of coagulation	√		√	√	√
positive regulation of collagen biosynthetic process	√		√	√
positive regulation of collagen metabolic process	√		√	√
protein maturation		√
protein maturation by peptide bond cleavage		√
protein processing		√
regeneration	√
regulation of blood coagulation	√	√	√		√	√
regulation of body fluid levels	√	√	√	√		√	√
regulation of coagulation	√	√	√		√	√
regulation of collagen metabolic process	√			√
regulation of fibrinolysis					√
regulation of multicellular organismal metabolic process	√			√
regulation of response to external stimulus		√
response to wounding		√
tissue regeneration	√				√
tyrosine phosphorylation of STAT protein	√		√	√
wound healing		√	√			√	√
Number of connected GOBPs	22	17	16	14	12	9	5

ISSN: 1471-2164