Driver mutations signatures (left panel) and network modules (right panel) of four breast cancer subtypes. (Red indicates driver mutations, and cyan means the connection nodes. Left panel: the heat maps of the top ten high-frequency mutated genes of four subtypes. The column label: the patient samples ID of each subtype; the row label: ten high-frequency mutated genes ID. The red color in the heat map represents mutation detected in the corresponding sample, and the gray color indicates that a gene has no mutation in the corresponding sample. Right panel: the networks of top ranked mutations of four subtypes. Red nodes: mutated genes; green nodes: connections genes.