Chromosomal localisation and structures of the ABHD1 and Sec12 genes. (A) The human ABHD1 and Sec12 genes are at locus 2p23.3 on opposite strands. Genes encoded on + strand are shown above the line. They are flanked by the elastin microfibril interface located protein, EMILIN; ketohexokinase or fructokinase, KHK; cell growth regulatory with EF-hand domain, CGR11; solute carrier family 5 (sodium-dependent vitamin transporter) member 6 in the telomeric direction and by the NAS hypothetical protein, LOC165086; transcription factor 23, TCF23; SLC5A6; apoptosis related protein, APR-3 and the trifunctional protein of pyrimidine biosynthesis, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, CAD genes in the centromeric direction. Genes orientated in the opposite direction to ABHD1 are shown below the line. (B) The gene structures of the ABHD1 and Sec12 genes. The human genomic sequence corresponding to these two cDNAs is located on BAC clone RP11-195B17 and both genes have nine exons and CpG islands. The ORF is indicated by closed boxes. The sequences around the initiation methionine codons are shown, as are the stop codons and the polyadenylation sites. The size of the exons and introns are indicated.