Figure 1

Order and chromosomal orientation of clones mapped by FISH in this study (D) aligned with integrated NCBI maps dynamically changing through the time periods April 2001 (Build 22), August 2001 (Build 25), April 2002 (Build 29) and November 2002 (Build 31) (A-D). Genes and sites relevant to reagents used in this study are shown in bold or in grey-filled boxes, and if not marked, were not found in that particular Build. Also indicated are key STS sites common between previously published maps of this region [1–4] (C,D). For A and B, only D10S571, D10S1266, LGI1, GOT1 and WNT8B are shown, in addition to markers relevant to the reagents of this study (if found) to illustrate major rearrangements of database contigs within this region through the different NCBI Builds. The locations of 7 additional cancer-related genes are indicated in C and D, with the relative locations of clones used in the present study shown aligned with the recently released Build 31 (D) (see Results for further details). Arrowheads above maps B-D correspond to cancer-related chromosome breakpoint sites associated with disruption of the LGI1 gene [23, 46], HOX11 [8–13] and NFKB2/LYT-10 [21, 22]. The cancer-related gene MXI1[30] maps ~7.5 Mb telomeric of GERP1.