Figure 5

The respiratory components of E. coli and Salmonella . This figure gives an overview of the respiration of E. coli and Salmonella and how it is influenced by the GATC network. As can be seen, the large majority of enzymes involved in respiration are affected, directly or indirectly, by the GATC network. Listed on the left hand side are the gene complexes that make up the dehydrogenases, together with the reactions they catalyse. The resulting reducing equivalents are passed through the common quinone pool and are used by the oxidoreductases, listed on the right hand side, together with the reactions they catalyse. Also given are the means by which the various dehydrogenases and oxidoreductases are affected through the GATC cluster network. "Heme": the gene complex contains a heme, whose synthesis is blocked by a GATC cluster in gltX. "NarL/ NarP" the gene complex is under control by NarL/ NarP whose respective genes are blocked by a GATC cluster. "Selenocysteine": the gene complex contains selenocysteine whose insertion into the protein is blocked (GATC clusters in selB/ cysN). "GATC cluster": the gene complex itself contains a GATC cluster. For further details please refer to the results section."Sal.": Salmonella.