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Table 3 Annotation and Gene Ontology characteristics of 11 honey bee EST contigs sharing significant similarity with mammalian but not with other vertebrate or invertebrate sequences. In all cases, the best match was with human proteins. For these 11 out of 23 contigs we could retrieve functional information.

From: The use of Open Reading frame ESTs (ORESTES) for analysis of the honey bee transcriptome

Apis EST contig E-score valuea GO, Biological processb Human LOCUS ID GenBank annotation Additional information
  Human Insect    
437 2e-67 NA without result NM_019116: ubiquitin binding protein ubiquitin-specific protease domain
663 3e-10 NA without result NM_182830: MAM domain contactin 5; neural adhesion molecule
1081 5e-07 9.7 without result NM_013041: RAB3A interacting protein (rabin3)-like1 guanin nucleotide exchange factor domain
1425 8e-27 NA without result NM_182565: hypothetical protein MGC29814 TBP-associated factor 4; TATA box binding protein
1674 4e-82 NA without result NM_172374: interleukin 4 induced 1 none
1953 7e-11 NA without result NM_024707: gem (nuclear organelle) associated protein spliceosomal snRNP biogenesis
2807 8e-07 5e-04 regulation of physiological process NM_138457: forkhead box P4 transcription factor activity
2896 4e-05 0.002 reproduction, metabolism NM_004654: ubiquitin-specific protease 9 ubiquitin thiolesterase activity
3167 2e-27 7e-05 cell communication NM_033046: rhotekin signal transduction
3347 5e-26 7.5 without result NM_014006: PI-3-kinase-related kinase SMG-1 involved in nonsense-mediated mRNA decay
3374 1e-10 0.18 cell communication, NM_014035: sorting nexing 24 intracellular signaling cascade
  1. aE-value of the contig alignment with human or known insect sequences, NA: did not show any alignment; bGene Ontology results on Biological Process, FatiGO level 3, cadditional information obtained from Entrez Gene – NCBI and GOA link (GOAnnotations@EBI – European Bioinformatics Institute).