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Table 1 Description of C. elegans – human orthologs. The Swiss-Prot accession numbers are given for the worm sequences and their human orthologs. TM: the number of transmembrane regions predicted using the consensus of nine different methods in the SFINX tool. Bootstrap support (%) is given for the inferred speciation node in the phylogenetic tree constructed using PHYLOWIN with PAM distances. Identity (%): sequence percentage identity from the Blastp output between the C. elegans gene and the nearest human ortholog. Four of the worm genes are predicted to have two splice variants (a and b). However, there are only small differences in the protein sequences between the two variants, except for R155.1. Splice variant R155.1b is predicted to have a truncation of more than one hundred amino acids in the N-terminus compared to R155.1a. The PF03062 domain (MBOAT) is still present in both splice variants. The protein sequence for R155.1a was used in the phylogenetic analysis.

From: Functional characterization in Caenorhabditis elegans of transmembrane worm-human orthologs

C. elegans orthologs TM Pfam-A domains Human orthologs Bootstrap support (%) Identity (%) Nearest human ortholog with putative function
C30H6.2 (Q9XVR4) 6 PF02535 (ZIP) Q9H6T8, Q9NXC4, Q96NN4 57 50 Q9H6T8: SLC39A4, involved in intestinal absorption of zinc.
T11F9.2a (Q8I4G0), T11F9.2b (Q22395) 7 PF02535 (ZIP) Q15043, Q96SM9, Q9C0K1, Q96BB3 91 30 Q9C0K1: BIGM103, involved in intracellular zinc retention and accumulation.
H13N06.5 (Q9XTQ7) 9 PF02535 (ZIP) Q92504 98 52 Transport of zinc out of ER2 and other intracellular stores.
T28F3.31 (Q9XUC4) 7* PF02535 (ZIP) Q92504 79 38 Transport of zinc out of ER2 and other intracellular stores.
T01D3.5 (Q9XVJ5) 8 PF02535 (ZIP) Q9NUM3 99 38 Function unknown.
F40F9.1a (Q8MQ56), F40F9.1b (Q8MQ55) 7 PF01027 (UPF0005) Q9BWQ8, Q969X1 70 39 Q9BWQ8: Lifeguard protein, protects cells from Fas-mediated cell death.
F40F9.2 (Q20241) 7 PF01027 (UPF0005) Q9BWQ8, Q969X1 70 40 Q9BWQ8: Lifeguard protein, protects cells from Fas-mediated cell death.
F08F1.7 (O17388) 9* PF02990 (EMP70) Q99805 100 62 Endosomal integral membrane protein.
ZK858.6a (Q94422) 9 PF02990 (EMP70) Q92544 100 53 Function unknown.
ZK858.6b (Q7YTF9) 9*      
F14F3.3 (Q19468) 9 PF03062 (MBOAT) Q96N66, Q99908 100 27 Q99908: BB1 protein, malignant cell expression-enhanced gene.
R155.1a (O01925) 8 PF03062 (MBOAT) Q92980 100 32 Function unknown.
R155.1b (Q86DC4) 4      
C36B1.12 (Q93346) 9* PF04258 (Peptidase_A22B) Q8TCT7, Q8TCT8, Q8IUH8 100 30 Q8TCT7: Presenilin-like protein, may act as intra-membrane protease.
sft-4(Q18864) 7 PF02077 (SURF4) O15260 100 55 Surfeit locus protein 4, probable ER2 integral membrane protein.
D2013.10 (O62126) 6 None Q15055 98 53 Function unknown.
T04A8.12 (Q22141) 6 None Q9UHJ9 50 35 FRAG1 (FGFR (fibroblast growth factor receptor) activating gene 1).
Y6B3B.10 (Q9XWE9) 6 PF03798 (LAG1) P27544 99 37 Function unknown.
ZK721.1 (Q9GYF0) 10* None Q9NXL6, Q9Y357 97 34 Function unknown.
  1. 1 T28F3.3 was initially included because of strong similarity to Q92504; however, the phylogenetic analysis showed that it is probably an outparalog to the human gene.
  2. 2 ER = endoplasmic reticulum.
  3. * predicted to have a N-terminal signal peptide.