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Table 1 Groups and families of ePKs in the TriTryps

From: Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi

Group Family T. brucei T. cruzi a L. major Group Family T. brucei T. cruzi L. major
AGC (na)b 6 7 6 Other AUR 3 3 3
  NDR 2 1 1   CAMKK 4 4 4
  PKA 3 3 3   CK2 2 2 2
  RSK 1 1 1   NAK 0 1 1
  Total 12 12 11   NEK 20 22 22
CAMK (na) 7 7 9   PEK 3 2 3
  CAMKL 7 6 7   PLK 2 2 1
  total 14 13 16   TLK 2 1 1
CK1 CK1 4 7 6   ULK 1 1 1
  TTBK 1 1 1   VPS 1 1 0
  Total 5 8 7   WEE 1 2 2
CMGC (na) 1 1 1   total 39 42 40
  CDK 11 10 11 STE (na) 7 8 10
  CLK 4 5 4   STE7 2 2 2
  DYRK 7 7 8   STE11 14 18 21
  GSK 2 2 2   STE20 2 3 1
  CDKL (MAPK-like)c 2 1 2   total 25 31 34
  MAPKd 10 11 12 Unique   19 23 26
  RCK (MAPK-like)c 3 3 3 TOTAL ePK   156 171 179
  SRPK 2 2 2      
  total 42 42 45 Non-catalytic   13 16 16
  1. a Multiple copies of TcCRK7 were counted as one gene. The number of tandem repeated CK1 genes in T. cruzi is not clear. One putative T. cruzi PEK gene is truncated by the contig end for both alleles, and is assigned on the basis of orthology in the non-catalytic sequence.
  2. bna, not assigned to a family.
  3. c CDKL and RCK families are related to MAPKs and CDKs [57] but are classified separately in the human kinome [21].
  4. d One MAPK-like sequence in T. brucei and two in T. cruzi and L. major lack the typical regulatory motifs (see Table S1). One MAPK-like COG, which fell below the E-value criterion, was designated as MAPK on the basis of regulatory motifs.