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Table 2 Additional Pfam domains on trypanosomatid ePKs

From: Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi

Pfam Tba Tc Lm TriTrypb Other kinomesb Comments
Armadillo 0 1 1 ULK NEK, STE11, ULK related to HEAT
B-box Zn finger 0 0 1 NEK nd Zn binding
C1-like 0 1 1 AGC AGC possible diacylglyerol binding
cap-gly 1 1 1 CAMK VPS15 cytoskeleton associated
cNMP binding 0 1 2 STE AGC cyclic nucleotide binding
EF Hand 2 2 2 CAMK CAMK Calcium binding
FHA 1 2 4 CAMK, STE CAMK phosphopeptide binding
FYVE 1 2 1 AGC nd Zn binding
HAMP 0 1 0 STE nd in diverse signaling proteins
HEAT 1 1 0 ULK VPS15 protein interaction
HECT 0 0 1 unique nd ubiquitin transferase
Kelch 1 0 0 unique nd propeller structure
LRR 1 1 1 CAMKK TK, TKL, plantrk protein interaction
MORN 1 1 1 STE TKL, unique unknown function
PAS 1 1 1 STE CAMK, TKL signal sensor
PH 6 7 6 AGC, NEK AGC, CAMK, STE20 Phosphatidylinositol binding
PKC-Cterm 0 0 2 AGC AGC found on protein kinases
POLO 1 1 1 POLO POLO POLO kinase region
PX 1 1 1 AGC AGC phosphoinositide binding
RWD 1 0 0 PEK PEK unknown function
TPR2 0 2 1 STE, unique plantrk protein interaction
zf-C2H2 2 1 1 unique AUR zinc binding
  1. a The number of genes bearing the indicated Pfam domain.
  2. b Classification of ePKs bearing the designated domain in the TriTryps or other kinomes (as detected in S. cerevisiae, Schizosaccharomyces pombe, P. falciparum, C. elegans, D. melanogaster, A. thaliana, and Oryza sativa) using the web tools at the Kinases in Genomes (KING) website [81]. The plantrk group is comprised of serine/threonine receptor kinases present in plant; nd, none detected.