Figure 1

Significant differences in gene expression profiles in patients with SARS or bacterial infection. Using a probe set with 6,525 annotated genes, global gene expression was analyzed by (A) variation distribution in peripheral blood specimens from patients with acute SARS (AS), recovering SARS (RS), bacterial infections (IN), and normal controls (NC). (B) In the hierarchical clustering of relative change in gene expression using a probe set of 885 filtered genes (gene vector >0.5 SD), red indicates upregulation and green indicates downregulation in gene expression relative to a common reference that was the pooled amplified RNA from 11 normal controls. (C) Using the 885-gene set, singular value decomposition (SVD) analysis by two eigenvectors showed three distinguished clusters of AS (red ●), IN (green ▲), and NC (blue ▮) groups, with the RS (red ○) specimens scattering among AS and IN.