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Table 2 Fold change of induced gene expression in B lymphoblasts treated with ionophore A23187. Genes listed here showed a 2-fold increase or more in gene expression in at least one of the three B lymphoblasts cultured for 48 h with 200 nM A23187. Data are fold changes calculated from hybridization values in treated versus non treated cells for each one of the B lymphoblasts respectively (see additional file 1). For each functional group, the genes were ordered by using a program for gene clustering. *Genes basally expressed differently in the cell lines (see additional file 2).

From: Identification of genes involved in Ca2+ ionophore A23187-mediated apoptosis and demonstration of a high susceptibility for transcriptional repression of cell cycle genes in B lymphoblasts from a patient with Scott syndrome

Accession no.

control

daughter's

Scott

Gene definition

    

Chemokines

D90144

2.05

2.79

1.80

LD78 alpha

M26383

12.28

15.78

8.70

MONAP

D43768

11.58

30.28

11.87

SCM-1*

NM002984

5.46

8.43

4.63

SCYA4

U83171

9.70

2.44

2.29

macrophage-derived chemokine*

U02020

3.79

4.71

3.37

PBEF

X13274

4.19

3.20

9.17

IFN-gamma

D12614

2.83

3.91

3.01

TNF-beta

    

Cell proliferation

AB044548

7.36

1.83

1.77

P/OKcl.6*

X79067

2.40

1.98

1.56

ERF-1

X59892

4.29

4.83

4.71

IFN-inducible gamma 2

AB021663

7.95

12.89

5.23

leucine-zipper protein

D84224

7.47

10.92

7.44

methionyl tRNA synthetase

X52560

4.32

4.10

3.70

NF-IL6

AF064105

3.44

3.00

2.67

Cdc14B3 phosphatase

AF022375

2.86

2.22

2.63

VEGF

X77366

2.66

2.51

2.42

HBZ17

M91196

2.02

3.70

3.47

DNA-binding protein

J04076

3.67

3.88

3.41

EGR2

U09587

2.01

2.13

2.20

glycyl-tRNA synthetase

U12767

3.84

4.00

7.02

MINOR

U27655

3.70

1.76

3.60

RGP3

U88964

-1.14

1.14

2.57

HEM45*

D87116

1.67

1.79

2.71

MAP kinase kinase 3b

    

Metabolism

U08997

2.03

2.41

1.82

glutamate dehydrogenase

X01630

12.51

17.87

15.17

argininosuccinate synthetase

M55543

6.11

4.96

4.47

GPB-2*

M37721

2.20

2.27

2.77

peptidylglycine alpha-amidating monooxygenase

AF081195

2.48

3.98

2.18

CalDAG-GEFII

U53347

2.05

2.21

2.25

neutral amino acid transporter B

M77836

2.86

3.08

2.36

pyrroline 5-carboxylate reductase

X05908

2.18

3.45

2.77

Lipocortin*

X92720

2.05

2.10

2.34

phosphoenolpyruvate carboxykinase

AK000379

2.82

2.91

3.10

similar to asparagine synthetase

X76488

2.43

2.48

2.44

lysosomal acid lipase*

S52784

3.36

3.86

4.85

cystathionine gamma-lyase

U26398

1.98

3.69

2.77

inositol polyphosphate 4-phosphatase

AF002020

1.03

1.33

3.00

Niemann-Pick C disease protein

M11233

1.23

1.21

3.59

cathepsin D*

    

Metallothionein family

M13003

2.85

10.83

1.90

metallothionein-I F*

K01383

3.62

4.60

3.90

metallothionein-I A

D13365

2.74

2.46

2.36

GIF

X64177

1.91

2.79

1.82

metallothionein

M10942

1.93

2.49

2.17

metallothionein-I E

    

Micellaneous

M31516

5.63

4.00

3.57

decay-accelerating factor

D90224

4.84

3.93

2.16

GP 34*

M27492

2.28

3.60

3.07

IL-1 receptor*

AF104032

2.43

3.06

2.83

LAT1

X03444

2.79

2.02

3.66

lamin A*

U33017

1.90

2.62

1.56

SLAM

U16954

1.97

2.35

2.81

AF1q*

U64863

4.14

4.57

3.41

PD-1*

Y14039

2.25

3.48

2.51

CASH alpha*

U76248

2.47

2.81

2.68

SIAH2

M80899

2.13

1.33

2.69

AHNAK*

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BMC Genomics

ISSN: 1471-2164

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