Figure 1

Domain organization of Dictyostelium formins. With few exceptions, Dictyostelium formins conform to the domain structure GBD/FH3-FH1-FH2-DAD. Diagrams have been aligned with the FH2 domain. Regions with high probability of coiled coil structure are depicted as thin gray rectangles. C1 and C2 correspond to protein kinase C conserved regions 1 and 2, respectively. FHA is a forkhead-associated domain. Numbers inside the FH1 boxes indicate the number of XPPPPP motifs. Triangles denote the position of introns. Only introns placed in coding regions are shown. Intron positions shared by two or more genes have been labeled with letters.