Table 3 Biological process classification of 175 genes derived from three analyses. The 149 genes derived from the ANOVA analysis of xenograft versus parental cell line data, the 54 genes identified by the linear discriminant analysis and the 12 genes derived from the intersect of ANOVA of individual tumors are shown. Gene Ontology terms were extracted at level 3 for the Unigene gene names. Not shown are genes multiply annotated into additional singular categories or genes absent from the Gene Ontology. Percentages were calculated from a total of 317 classifications into 31 Biological Process terms.
GO | Process | % | Genes |
|---|---|---|---|
GO:0007154 | cell communication | 26.8% | HDGF PTGER3 CD44 TAS2R16 GALR2 IGFBP3 COL5A1 OR1F1 SORCS3 FZD1 LAMB3 SELPLG GFRA3 IL26 CXCR4 PDAP1 SSTR3 ENSA CD151 COL9A1 OPCML GPR145 GPR44 EPHA3 TNC GPR80 HAS1 BGLAP EFNA1 EBI2 EDN3 TSHR F2R PRSS11 NRP1 OMP MC2R INHBB OR7A17 IL8 AGTR2 GPR48 CHODL CXCL1 OR1F10 CHRM1 GPR10 GPR57 NID2 GPR6 LAMB1 CCR5 SPP1 ADCYAP1R1 CXCL11 PCSK5 GPR23 RAP2B IFNGR2 IL7 COL12A1 PYY CXCL2 PCDHB9 GPR110 CD164 PBEF KLRB1 FN1 BSG IGSF6 FBLN5 STC2 ANGPT2 ADORA2B PF4 IL12B FPR1 GPLD1 CCR4 NPY1R ESR1 GNAO1 ITGA4 KITLG |
GO:0008151 | cell growth and/or maintenance | 1. 55% | HDGF IGFBP3 SORCS3 TSPAN-3 CXCR4 PDAP1 SSTR3 ENSA TRPV2 SLC39A4 TF EMP3 HBE1 CACNA1H TSHR F2R COL5A2 PRSS11 NRP1 INHBB CLCA4 IGFBP7 IL8 RBP4 MGC2376 CXCL1 CHRM1 A2M CP CD81 CCR5 KTN1 SPP1 SCAMPI OGFR IL7 TRPM5 NOV PYY CD164 PBEF SLC16A8 PLEC1 ANGPT2 HCN2 IL12B EMP2 ESR1 KITLG |
GO:0009605 | response to external stimulus | 12.6% | TAS2R16 OR1F1 IL26 CXCR4 ENSA TRPV2 GPR44 EBI2 EDN3 F2R OMP RNASE6 INHBB OR7A17 IL8 HLA-A RBP4 CXCL1 TIMP3 SEPP1 CD81 CCR5 SPP1 CXCL11 IFNGR2 IL7 CST7 CXCL2 CD164 CR1 KLRB1 FN1 IGSF6 STC2 ADORA2B PF4 IL12B FPR1 CCR4 IFI27 |
GO:0008152 | metabolism | 7.9% | PTGER3 LIPF MMP7 EPHA3 KLK11 HAS1 CMA1 F2R MMP10 FAP PRSS11 RNASE6 INHBB MMP8 CHRM1 SEPP1 CD81 PCSK5 RNASE4 KLK13 ADAM28 FIBL-6 TLL1 IL12B ESR1 |
GO:0009653 | morphogenesis | 7.9% | BDNF LAMB3 TSPAN-3 GFRA3 CXCR4 CACNA1H BGLAP F2R NRP1 INHBB IL8 AMELY CXCL1 CHRM1 CCR5 SPP1 COL1A1 COL12A1 PCDHB9 FGF19 ANGPT2 TLL1 PF4 IL12B GNAO1 |
GO:0006950 | response to stress | 6.0% | IL26 CXCR4 F2R IL8 CXCL1 SEPP1 CCR5 SPP1 CXCL11 IFNGR2 IL7 CXCL2 CR1 KLRB1 FN1 ADORA2B IL12B FPR1 CCR4 |
GO:0006928 | cell motility | 3.5% | GALR2 TSPAN-3 HAS1 CACNA1H F2R NRP1 IL8 PYY FN1 FPR1 GNAO1 |
GO:0008219 | cell death | 2.5% | PTGER3 CXCR4 SSTR3 EMP3 F2R AGTR2 SPP1 EMP2 |
GO:0016265 | death | 2.5% | PTGER3 CXCR4 SSTR3 EMP3 F2R AGTR2 SPP1 EMP2 |
GO:0030154 | cell differentiation | 1.9% | BGLAP INHBB SPP1 FGF23 PF4 IL12B |
GO:0007397 | histogenesis and organogenesis | 1.6% | CXCR4 COL9A1 NRP1 IL7 KITLG |
GO:0007599 | hemostasis | 1.3% | SERPINC1 TFPI2 F2R PF4 |
GO:0000003 | reproduction | 0.9% | SPAG11 ADCYAP1R1 ADAM28 |
GO:0007631 | feeding behavior | 0.9% | GALR2 PYY NPY1R |
GO:0009405 | pathogenesis | 0.9% | CXCR4 EDN3 TSHR |
GO:0008015 | circulation | 0.9% | CACNA1H EDN3 AGTR2 |
GO:0046849 | bone remodeling | 0.9% | BGLAP AMELY SPP1 |
GO:0007586 | digestion | 0.6% | GALR2 PYY |
GO:0019098 | reproductive behavior | 0.3% | PI3 |
GO:0030198 | extracellular matrix organization and biogenesis | 0.3% | COL14A1 |