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Table 4 Kegg Biochemical pathway mappings for A. caninum and A. ceylanicum clusters

From: Investigating hookworm genomes by comparative analysis of two Ancylostoma species

  AC Clusters per library   AE Clusters per library   Total # of enzymes in KEGG
KEGG CATEGORY REPRESENTEDa Clb iL3 taL3 ssL3 Mixed Enzc Clb iL3 Ad Mixed Enzc  
1. Carbohydrate metabolism             
   1.1 Glycolysis / Gluconeogenesis 23 13 0 5 5 22 25 10 11 4 23 40
   1.2 Citrate cycle (TCA cycle) 17 8 0 4 5 16 15 4 8 3 15 23
   1.3 Pentose phosphate pathway 9 3 0 4 2 9 12 5 3 4 8 34
   1.4 Pentose and glucuronate interconversions 8 3 0 3 2 9 9 5 4 0 8 53
   1.5 Fructose and mannose metabolism 14 6 0 4 4 15 20 7 11 2 15 61
   1.6 Galactose metabolism 10 4 0 4 2 8 12 6 5 1 12 37
   1.7 Ascorbate and aldarate metabolism 7 4 0 2 1 4 5 5 0 0 4 29
   1.8 Pyruvate metabolism 25 11 0 11 3 23 27 8 17 2 26 67
   1.9 Glyoxylate and dicarboxylate metabolism 13 6 0 5 2 14 9 1 5 3 17 58
   1.10 Propanoate metabolism 22 7 1 10 4 20 25 11 8 6 22 46
   1.11 Butanoate metabolism 22 9 1 7 5 23 29 14 14 1 26 52
   1.12 C5-Branched dibasic acid metabolism 4 3 0 1 0 2 2 1 0 1 1 20
   1.13 Inositol metabolism 6 2 0 1 3 4 7 2 3 2 4 5
2. Energy metabolism             
   2.1 Oxidative phosphorylation 24 7 0 6 11 11 33 10 14 9 13 14
   2.2 ATP synthesis 8 2 0 3 3 1 11 4 3 4 1 1
   2.4 Carbon fixation 11 3 0 3 5 11 11 3 5 3 13 23
   2.5 Reductive carboxylate cycle (CO2 fixation) 12 7 0 1 4 8 9 2 4 3 7 13
   2.6 Methane metabolism 6 4 0 0 2 5 6 0 4 2 6 26
   2.7 Nitrogen metabolism 11 2 0 5 4 14 12 5 5 2 15 64
   2.8 Sulfur metabolism 5 1 0 1 3 9 6 3 1 2 9 30
3. Lipid metabolism             
   3.1 Fatty acid biosynthesis (path 1) 6 2 0 3 1 11 7 3 3 1 6 14
   3.2 Fatty acid biosynthesis (path 2) 8 2 0 5 1 6 6 3 2 1 5 8
   3.3 Fatty acid metabolism 14 6 1 6 1 17 21 13 7 1 16 28
   3.4 Synthesis and degradation of ketone bodies 2 0 0 1 1 2 8 4 3 1 3 6
   3.5 Sterol biosynthesis 4 1 1 2 0 4 4 2 2 0 9 35
   3.6 Bile acid biosynthesis 11 7 1 2 1 11 11 6 4 1 10 27
   3.8 Androgen and estrogen metabolism 7 5 0 2 0 9 7 4 3 0 8 26
4. Nucleotide metabolism             
   4.1 Purine metabolism 27 11 0 11 5 28 32 14 11 7 32 99
   4.2 Pyrimidine metabolism 16 8 1 5 2 15 22 9 12 1 22 61
   4.3 Nucleotide sugars metabolism 6 4 0 0 2 3 4 2 2 0 4 30
5. Amino acid metabolism             
   5.1 Glutamate metabolism 11 3 0 5 3 14 16 8 7 1 18 36
   5.2 Alanine and aspartate metabolism 14 1 0 8 5 15 14 5 6 3 15 38
   5.3 Glycine, serine and threonine metabolism 19 7 0 9 3 14 21 8 10 3 24 56
   5.4 Methionine metabolism 6 1 0 4 1 9 6 5 1 0 8 24
   5.5 Cysteine metabolism 8 2 0 2 4 11 7 5 2 0 9 23
   5.6 Valine, leucine and isoleucine degradation 16 3 1 8 4 16 22 11 6 5 18 32
   5.7 Valine, leucine and isoleucine biosynthesis 7 1 0 4 2 7 9 6 2 1 8 15
   5.8 Lysine biosynthesis 11 1 0 6 4 10 9 4 3 2 8 31
   5.9 Lysine degradation 19 8 0 8 3 14 19 12 6 1 17 47
   5.10 Arginine and proline metabolism 18 4 0 8 6 20 22 11 7 4 20 71
   5.11 Histidine metabolism 10 4 0 4 2 8 10 5 4 1 8 39
   5.12 Tyrosine metabolism 18 8 0 7 3 19 19 11 5 3 19 67
   5.13 Phenylalanine metabolism 13 5 0 3 5 11 14 7 6 1 12 40
   5.14 Tryptophan metabolism 17 8 0 8 1 15 22 16 4 2 18 61
   5.15 Phenylalanine, tyrosine and tryptophan biosynthesis 5 1 0 2 2 6 4 2 0 2 7 31
   5.16 Urea cycle and metabolism of amino groups 10 1 0 5 4 14 10 2 6 2 11 35
6. Metabolism of other amino acids             
   6.1 beta-Alanine metabolism 14 4 1 7 2 13 11 8 1 2 10 32
   6.2 Taurine and hypotaurine metabolism 1 0 0 0 1 1 2 2 0 0 3 14
   6.3 Aminophosphonate metabolism 4 0 0 3 1 3 5 2 3 0 5 15
   6.4 Selenoamino acid metabolism 7 0 0 4 3 12 12 6 4 2 15 22
   6.5 Cyanoamino acid metabolism 2 1 0 1 0 1 7 5 1 1 6 19
   6.6 D-Glutamine and D-glutamate metabolism 2 0 0 1 1 2 2 1 0 1 2 12
   6.7 D-Arginine and D-ornithine metabolism 3 1 0 0 2 2 3 0 2 1 2 10
   6.9 Glutathione metabolism 5 1 0 0 4 4 9 5 3 1 6 27
7. Metabolism of complex carbohydrates             
   7.1 Starch and sucrose metabolism 18 2 0 13 3 18 20 13 6 1 20 75
   7.2 N-Glycans biosynthesis 7 4 0 1 2 7 7 2 4 1 9 27
   7.3 O-Glycans biosynthesis 3 1 0 1 1 2 6 5 1 0 3 8
   7.5 Aminosugars metabolism 6 3 0 2 1 6 10 5 5 0 10 39
   7.8 Glycosaminoglycan degradation 1 1 0 0 0 1 1 1 0 0 1 13
   7.9 Chondroitin / Heparan sulfate biosynthesis 5 3 0 1 1 4 6 2 4 0 4 18
   7.10 Keratan sulfate biosynthesis 1 0 0 1 0 1 2 1 1 0 1 6
8. Metabolism og complex lipids             
   8.1 Glycerolipid metabolism 24 10 0 9 5 22 25 10 13 2 22 80
   8.3 Inositol phosphate metabolism 8 4 0 4 0 4 8 5 2 1 3 25
   8.4 Sphingophospholipid biosynthesis 1 1 0 0 0 1 2 1 1 0 2 8
   8.5 Phospholipid degradation 3 2 0 0 1 3 1 1 0 0 1 11
   8.6 Sphingoglycolipid metabolism 11 1 1 9 0 7 10 8 2 0 4 20
   8.9 Globoside metabolism 2 1 0 1 0 2 2 1 1 0 1 12
   8.11 Prostaglandin and leukotriene metabolism 8 2 0 1 5 8 7 4 3 0 6 19
9. Metabolism of cofactors and vitamins             
   9.2 Riboflavin metabolism 4 1 0 3 0 2 2 2 0 0 2 13
   9.3 Vitamin B6 metabolism 6 4 0 1 1 3 6 4 1 1 5 23
   9.4 Nicotinate and nicotinamide metabolism 11 2 0 7 2 7 15 8 7 0 7 32
   9.5 Pantothenate and CoA biosynthesis 8 2 0 4 2 9 8 6 2 0 7 27
   9.7 Folate biosynthesis 5 2 1 0 2 5 6 1 4 1 5 25
   9.8 One carbon pool by folate 5 3 0 2 0 10 7 3 3 1 8 24
   9.10 Porphyrin and chlorophyll metabolism 18 4 0 10 4 12 27 15 8 4 13 56
   9.11 Ubiquinone biosynthesis 19 10 0 5 4 13 28 11 14 3 14 22
10. Biosynthesis of secondary metabolites             
   10.1 Terpenoid biosynthesis 0 0 0 0 0 0 2 0 2 0 4 12
   10.3 Flavonoids, stilbene and lignin biosynthesis 6 3 0 1 2 7 8 5 3 0 7 39
   10.4 Alkaloid biosynthesis I 5 2 0 3 0 6 3 3 0 0 5 36
   10.8 Streptomycin biosynthesis 2 0 0 2 0 3 4 2 1 1 4 14
   10.9 Erythromycin biosynthesis 2 0 0 2 0 3 3 2 1 0 3 6
11. Biodegradation of xenobiotics             
   11.4 Nitrobenzene degradation 4 1 0 3 0 5 4 2 1 1 3 17
   11.9 Tetrachloroethene degradation 6 4 0 1 1 3 2 2 0 0 3 5
   11.10 Styrene degradation 4 2 0 2 0 3 6 5 0 1 5 18
   11.1 gamma-Hexachlorocyclohexane degradation 6 3 0 3 0 5 5 3 2 0 4 12
   11.1 Fluorene degradation 3 1 0 2 0 4 2 2 0 0 2 13
   11.2 Benzoate degradation via CoA ligation 22 8 1 10 3 18 25 14 10 1 18 38
   11.2 Benzoate degradation via hydroxylation 7 2 0 5 0 7 5 4 1 0 5 45
  1. aA. caninum – 839 multiple and 786 unique mappings; A. ceylanicum – 957 multiple and 840 unique mappings. b Cluster, c Enzymes