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Table 2 Differently regulated (p ≤ 0.05) solute carriers with a minimum absolute fold change of four in pair-wise comparisons of adjoining intestinal segments. Bold cases indicate fold changes of five or higher (Means ± SDs, log2 scale, n = 3 or 9, respectively.).

From: Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes

Gene Name D > J D < J J > I J < I I > C I < C SI > C SI < C Literaturea Gene aliases References
Slc10a2     5.0 ± 1.2      Mouse and Human: Highly expressed in I ASBT; ISBT [36, 37, 53]
Slc12a4      2.6 ± 0.5   2.9 ± 0.5   - KCC1; RBCKCC1  
Slc13a1 2.8 ± 0.4    2.2 ± 0.5      Mouse: D/J ~ C < I; Human: only in kidney Nas1; NaSi-1 [54, 55]
Slc14a1      2.2 ± 1.2   2.1 ± 1.2   Human: Expressed in C; Rat: expressed in C UT-B [56, 57]
Slc17a6   2.2 ± 0.4        Rat: abundant in I DNPI, VGLUT2 [58]
Slc17a7 2.2 ± 0. 4         - Vglut1  
Slc19a3 3.8 ± 0.9         Human: D > J > C > I ThTr2 [59]
Slc1a1     2.4 ± 0.2 2.8 ± 0.2     Mouse: SI; rat: high in distal SI; human: intestine EAAC1, EAAC2, EAAT3, MEAAC1 [60-62]
Slc20a1       2.8 ± 0.4    Mouse: Present in D Glvr-1, Glvr1 [63]
Slc25a22      2.8 ± 0.3   2.7 ± 0.3   Human: SI - [64]
Slc26a2         2.5 ± 0.3 Human: C > SI Dtd, ST-OB [65]
Slc26a6      5.4 ± 0.2   6.1 ± 0.3   Mouse: D, J, I > C; Human: D>C>J~I, SI > C CFEX; Pat1 [66, 67]
Slc28a3      3.5 ± 1.2   3.5 ± 1.1   Human: D > J > I > C Cnt3 [68]
Slc2a1       3.9 ± 0.6   3.10 ± 0.3 Rat: Low expressed in SI; Human: expressed in colon carcinoma Glut1; Glut-1 [69, 70]
Slc2a2    4.0 ± 0.4   2.6 ± 0.5   5.2 ± 0.8   Human: expressed in SI Glut2; Glut-2 [71]
Slc2a5    2.6 ± 0.4     3.2 ± 0.7   Mouse: expressed in SI; Human: expressed in J Glut5; Slc5a [72, 73]
Slc34a2   4.0 ± 0.3   3.7 ± 0.2 4.9 ± 0.6     Mouse: expressed in SI and colon; Human: SI specific Npt2b; NaPi-2b [35, 74]
Slc35a1       2.1 ± 0.2   2.7 ± 0.3 - -  
Slc39a10     2.2 ± 0.3      - -  
Slc40a1 5.7 ± 0.3      2.5 ± 0.5    Mouse:high in D, not detected in I; Rat: expressed in D, C; Human: highly expressed in D MTP; Ol5; Pcm; Dusg; Fpn1; MTP1; IREG1; Slc11a3; Slc39a1 [75-77]
Slc4a7 2.4 ± 0.2      2.5 ± 0.2    Human: expressed in SI and C NBC3; NBCn1 [78]
Slc5a1      2.1 ± 0.1   2.7 ± 0.2   Mouse and Human: Specific for SI; Rat: possible expression in C Sglt1 [79, 80]
Slc6a14     3.0 ± 1.9   6.0 ± 1.8   7.7 ± 0.7 Mouse: SI < C; Human: weak in C, absent in SI ATB0plus; CATB0plus [81, 82]
Slc6a19      6.7 ± 0.6   6.8 ± 0.6   - B<0>AT1  
Slc6a4      3.1 ± 0.1   3.1 ± 0.2   Mouse and human: Intestinal enterocytes Htt; Sert; 5-HTT [83]
Slc7a7      3.6 ± 0.1   3.7 ± 0.2   Mouse: expressed in J, I; human: highly expressed in SI my+lat1 [84, 85]
Slc7a8   2.1 ± 0.4    5.2 ± 0.7   5.7 ± 0.8   Mouse: expressed in SI LAT2 [86]
Slc7a9      3.8 ± 0.2   3.4 ± 0.2   Mouse and human: expressed in SI CSNU3 [85]
Slco1b2 2.1 ± 1.1         - OATP2; Oatp4; lst-1; OATP-C; mlst-1; Slc21a6; Slc21a10  
  1. aD = Duodenum, J = Jejunum, I = Ileum, C = Colon, SI = Small intestine, - = No data found in the literature