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Table 2 Differently regulated (p ≤ 0.05) solute carriers with a minimum absolute fold change of four in pair-wise comparisons of adjoining intestinal segments. Bold cases indicate fold changes of five or higher (Means ± SDs, log2 scale, n = 3 or 9, respectively.).

From: Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes

Gene Name

D > J

D < J

J > I

J < I

I > C

I < C

SI > C

SI < C

Literaturea

Gene aliases

References

Slc10a2

   

5.0 ± 1.2

    

Mouse and Human: Highly expressed in I

ASBT; ISBT

[36, 37, 53]

Slc12a4

    

2.6 ± 0.5

 

2.9 ± 0.5

 

-

KCC1; RBCKCC1

 

Slc13a1

2.8 ± 0.4

  

2.2 ± 0.5

    

Mouse: D/J ~ C < I; Human: only in kidney

Nas1; NaSi-1

[54, 55]

Slc14a1

    

2.2 ± 1.2

 

2.1 ± 1.2

 

Human: Expressed in C; Rat: expressed in C

UT-B

[56, 57]

Slc17a6

 

2.2 ± 0.4

      

Rat: abundant in I

DNPI, VGLUT2

[58]

Slc17a7

2.2 ± 0. 4

       

-

Vglut1

 

Slc19a3

3.8 ± 0.9

       

Human: D > J > C > I

ThTr2

[59]

Slc1a1

   

2.4 ± 0.2

2.8 ± 0.2

   

Mouse: SI; rat: high in distal SI; human: intestine

EAAC1, EAAC2, EAAT3, MEAAC1

[60-62]

Slc20a1

     

2.8 ± 0.4

  

Mouse: Present in D

Glvr-1, Glvr1

[63]

Slc25a22

    

2.8 ± 0.3

 

2.7 ± 0.3

 

Human: SI

-

[64]

Slc26a2

       

2.5 ± 0.3

Human: C > SI

Dtd, ST-OB

[65]

Slc26a6

    

5.4 ± 0.2

 

6.1 ± 0.3

 

Mouse: D, J, I > C; Human: D>C>J~I, SI > C

CFEX; Pat1

[66, 67]

Slc28a3

    

3.5 ± 1.2

 

3.5 ± 1.1

 

Human: D > J > I > C

Cnt3

[68]

Slc2a1

     

3.9 ± 0.6

 

3.10 ± 0.3

Rat: Low expressed in SI; Human: expressed in colon carcinoma

Glut1; Glut-1

[69, 70]

Slc2a2

  

4.0 ± 0.4

 

2.6 ± 0.5

 

5.2 ± 0.8

 

Human: expressed in SI

Glut2; Glut-2

[71]

Slc2a5

  

2.6 ± 0.4

   

3.2 ± 0.7

 

Mouse: expressed in SI; Human: expressed in J

Glut5; Slc5a

[72, 73]

Slc34a2

 

4.0 ± 0.3

 

3.7 ± 0.2

4.9 ± 0.6

   

Mouse: expressed in SI and colon; Human: SI specific

Npt2b; NaPi-2b

[35, 74]

Slc35a1

     

2.1 ± 0.2

 

2.7 ± 0.3

-

-

 

Slc39a10

   

2.2 ± 0.3

    

-

-

 

Slc40a1

5.7 ± 0.3

    

2.5 ± 0.5

  

Mouse:high in D, not detected in I; Rat: expressed in D, C; Human: highly expressed in D

MTP; Ol5; Pcm; Dusg; Fpn1; MTP1; IREG1; Slc11a3; Slc39a1

[75-77]

Slc4a7

2.4 ± 0.2

    

2.5 ± 0.2

  

Human: expressed in SI and C

NBC3; NBCn1

[78]

Slc5a1

    

2.1 ± 0.1

 

2.7 ± 0.2

 

Mouse and Human: Specific for SI; Rat: possible expression in C

Sglt1

[79, 80]

Slc6a14

   

3.0 ± 1.9

 

6.0 ± 1.8

 

7.7 ± 0.7

Mouse: SI < C; Human: weak in C, absent in SI

ATB0plus; CATB0plus

[81, 82]

Slc6a19

    

6.7 ± 0.6

 

6.8 ± 0.6

 

-

B<0>AT1

 

Slc6a4

    

3.1 ± 0.1

 

3.1 ± 0.2

 

Mouse and human: Intestinal enterocytes

Htt; Sert; 5-HTT

[83]

Slc7a7

    

3.6 ± 0.1

 

3.7 ± 0.2

 

Mouse: expressed in J, I; human: highly expressed in SI

my+lat1

[84, 85]

Slc7a8

 

2.1 ± 0.4

  

5.2 ± 0.7

 

5.7 ± 0.8

 

Mouse: expressed in SI

LAT2

[86]

Slc7a9

    

3.8 ± 0.2

 

3.4 ± 0.2

 

Mouse and human: expressed in SI

CSNU3

[85]

Slco1b2

2.1 ± 1.1

       

-

OATP2; Oatp4; lst-1; OATP-C; mlst-1; Slc21a6; Slc21a10

 
  1. aD = Duodenum, J = Jejunum, I = Ileum, C = Colon, SI = Small intestine, - = No data found in the literature
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