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Table 1 Distribution of (TG/CA)n repeats in large gene families

From: (TG/CA)n repeats in human gene families: abundance and selective patterns of distribution according to function and gene length

Functional class and gene families Chromosomal Distributiona Average Gene Length (kb)b Genes in the family Proportion of Genes with (TG/CA)n repeats Number of Genes with (TG/CA)n repeats in three categories Average number of repeats per gene in three categories
      Type I Type II Type III Type I Type II Type III
Cell cycle classc(1)
Histone proteins family Dispersed 3.55 76 7.9 4 4 0 1.7 0.7 0
Immune and related functions class (9)
Interleukins Dispersed 14.67 43 32.6 9 6 2 1.3 0.9 0.1
Serine (or cysteine) proteinase inhibitor family Dispersed 17.87 32 50 12 9 2 1.4 0.8 0.2
Tumor necrosis factor (ligand) superfamily Dispersed 23.49 38 63.2 21 14 1 1.9 0.9 0.1
CD antigens Dispersed 26.96 54 46.3 20 11 3 1.9 1.3 0.3
Immunoglobulin heavy chains Intrachromosomal 0.38 162 0.6 1 0 0 1 0 0
Immunoglobulin kappa chains Intrachromosomal 0.55 73 5.5 1 3 0 0.3 3 0
Immunoglobulin lambda chains Intrachromosomal 0.35 88 0 0 0 0 0 0 0
Interleukin receptors family Dispersed 29.77 32 59.4 17 10 0 3.4 0.9 0
T cell receptor beta chains 84 Intrachromosomal, 9 Dispersed 0.42 94 9.6 5 3 1 0.8 0.3 0.1
Information class (6)
Homeo box Dispersed 5.48 40 25 6 6 1 1.2 0.9 0.2
Eukaryotic translation initiation factor Dispersed 36.54 33 45.5 13 10 3 2.1 0.9 0.2
Zinc finger protein family Dispersed 30.33 200 42.5 63 44 6 2.2 1.1 0.1
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptides Dispersed 43.44 32 62.5 17 8 2 1.5 0.6 0.1
Ribosomal protein genes Dispersed 4.94 96 6.3 6 0 0 1 0 0
Mitochondrial ribosomal protein genes Dispersed 16.92 74 23 14 12 1 1.8 0.9 0.1
Metabolism class (2)
Cytochrome P450 superfamily Dispersed 31.34 45 46.7 15 11 2 1.9 1 0.1
Proteasome subunit genes Dispersed 25.64 40 32.5 11 8 0 1.5 0.8 0
Signaling and Communication class (8)
G protein-coupled receptor family Dispersed 24.71 98 33.7 26 19 6 2.3 1.5 0.2
Tripartite motif-containing family Dispersed 29.29 40 60 19 12 2 1.6 0.8 0.1
Solute carrier family Dispersed 59.19 223 62.8 134 87 22 2.9 1.5 0.2
RAS oncogene family Dispersed 39.92 60 65 38 17 4 1.8 0.7 0.1
ATP-binding cassette transporters gene family Dispersed 73.85 44 68.2 29 24 4 3.6 2.5 0.3
Guanine nucleotide binding protein (G protein) polypeptide genes Dispersed 58.83 32 59.4 18 12 5 3.3 1.9 0.4
Potassium voltage-gated channel genes Dispersed 104.95 38 57.9 17 16 6 8.6 4.4 0.5
Protein phosphatase subunit genes Dispersed 65.62 59 57.6 27 22 7 2.9 1.8 0.3
Structure and motility class (1)
Collagen family Dispersed 132.83 37 86.5 29 23 10 5.7 2.3 0.4
  1. a: Chromosomal distribution of the members of gene families. 'Dispersed' indicates that members are distributed on different chromosomes.
  2. b: average gene length (in kb) for each gene family.
  3. c:Numbers in parentheses show the number of large sized gene families in each functional class.
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