Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains

BMC Genomics

Table 3 Significance levels for the main effects, two-way and three way interactions of MMU2 speed congenic donor region (DR), HG genotype (HG) (+/+ or hg/hg) and sex for selected traits

Donor region (DR)^a	6WK	9WK	G26	G29	NA	TF	AI
Proximal (2P)
DR	<.0001	<.0001	<.0001	<.0001	<.0001	<.0001	0.0079
HG	<.0001	<.0001	<.0001	<.0001	<.0001	<.0001	<.0001
Sex	<.0001	<.0001	<.0001	<.0001	<.0001	<.0001	0.9840
DR*HG	<.0001	0.0094	<.0001	0.0181	<.0001	0.0004	0.0183
DR*sex	0.0287	0.4783	0.0328	0.5938	0.0081	0.8780	0.5218
DRHGSex	0.4092	0.4206	0.6957	0.0882	0.1563	0.1618	0.0219
Proximal middle (2PM)
DR	<.0001	<.0001	<.0001	<.0001	<.0001	<.0001	<.0001
HG	<.0001	<.0001	<.0001	<.0001	<.0001	<.0001	<.0001
Sex	<.0001	<.0001	<.0001	<.0001	<.0001	<.0001	0.7248
DR*HG	0.7101	0.4667	0.1277	0.1110	0.7375	0.0026	0.0065
DR*sex	0.1441	0.3947	0.1095	0.4198	0.0104	0.9323	0.6994
DRHGSex	0.9437	0.2294	0.5748	0.0780	0.7697	0.0060	0.0002
Middle (2M)
DR	0.007	<.0001	0.0234	0.0002	0.0006	0.1703	0.9707
HG	<.0001	<.0001	<.0001	<.0001	<.0001	<.0001	<.0001
Sex	<.0001	<.0001	<.0001	<.0001	<.0001	<.0001	0.0064
DR*HG	0.0057	0.0563	0.1875	0.6072	0.4329	0.3437	0.0256
DR*sex	0.6968	0.0089	0.8356	0.0207	0.5162	0.1460	0.0437
DRHGSex	0.6205	0.1309	0.6500	0.0656	0.6704	0.0035	0.0004

6WK, weight at 6 weeks of age; 9WK, weight at 9 weeks of age; G26, weight gain from 2 to 6 weeks of age; G29, weight gain from 2 to 9 weeks of age; NA, nasal-anal body length; TF, total fat pad weight and AI, adiposity index. Significant effects after a Bonferroni correction (critical P < 0.0071) are in bold.
^a The distal (2D) donor region was not analyzed.

ISSN: 1471-2164