Table 3 Network focus genes from Ingenuity Pathways Analysis meeting differential expression cutoff of log2(ratio) ≥ ± 0.58 (1.5-fold increase or decrease) in at least 1 set of twins.
GenBank # | Gene | Neurological function or disease* |
|---|---|---|
Upregulated | Â | Â |
T49652 | ALOX5AP | neuronal signaling; possibly neurodegenerative diseases |
AA991590 | APOC1 | Â |
AA147170 | ALS4 | ataxia-ocular apraxia |
AA676466 | ASS | involved in nitric oxide production |
H21041 | ATF3 | extension of neurites |
AA702350 | AUTS2 | Asperger's syndrome |
AI341427 | BCAT1 | Â |
AA430367 | CBS | Â |
R00276 | CD38 | Â |
AA283949 | CDC14A | Â |
N67039 | CDK6 | Â |
H15267 | CHL1 | extension of neurites; organization of mossy fibers |
AA521362 | CR2 | Â |
AA884403 | CTF1 | myelination, differentiation of neurons |
AI371096 | DAPK1 | apoptosis of hippocampal neurons |
W00789 | DST | coalignment of neurofilaments, projection of axons; dysmyelination |
AA448599 | F13A1 | stroke |
AA149640 | FLT1 | VEGF-induced release of nitric oxide |
AA070902 | GGA2 | Â |
AI375302 | HMGB1 | extension of neurites |
AI539460 | IL7 | Â |
AA406546 | IL6ST | myelination, development of motor neurons, retraction of dendrites |
H09062 | MLSTD1 | Â |
W07099 | NAGLU | neurogenesis; vacuolation of neurons |
AA598611 | NR4A2 | neurogenesis; metabolism of dopamine |
AA707195 | NTRK2 | survival of Purkinje cells; apoptosis of neurons |
AA044267 | P2RX5 | Â |
H09567 | PAG | possible role in chronic neuroinflammation |
AA972337 | PAWR | Â |
AA489629 | PBEF1 | Â |
AI016039 | PLXNB2 | Â |
R80217 | PTGS2 | activation of astrocytes; spatial memory in mice; apoptosis of neurons |
AA495950 | RRM2B | Â |
R27457 | SLC38A2 | Â |
AI091460 | SOS1 | Â |
N63153 | SPRED1 | Â |
AI040821 | TERE1 | Â |
AA970358 | TSLP | Â |
Downregulated | Â | Â |
AA779727 | ADAM19 | development of septum |
R01732 | AMPD3 | Â |
AA478589 | APOE | quantity/morphology of neurons; neurite extension; learning in mice |
AA984646 | C7orf2 | Â |
AA448157 | CYP1B1 | Â |
AA446027 | EGR2 | myelination; development of motor neurons; routing of axons |
AA149096 | HCK | Â |
AA620511 | HSPA8 | Â |
W73790 | IGLL1 | Â |
AI380522 | ITGB7 | chronic demyelinating disease |
AA679503 | KIF1B | morphology and size of brain; neuron survival |
AA029283 | LARGE | Â |
T83159 | LSP1 | Â |
AI351740 | LTB | neurological disorder in rats |
AA022886 | PITPNC1 | Â |
AI126054 | PTK2 | Â |
AA173755 | ROBO1 | axon guidance |
AA457700 | SCD | neural regeneration |
AA504211 | TNFSF11 | Â |
N68465 | UAP1 | Â |