Gene expression profiling of lymphoblastoid cell lines from monozygotic twins discordant in severity of autism reveals differential regulation of neurologically relevant genes

Table 5 Significant genes exceeding expression cutoff across 5 sets of twins with ASD

Genbank#	Gene name or description	Mean log₂ (ratio)*
	Upregulated (log2(ratio) ≥ 0.58)
AA448599	F13A1, clotting factor XIIIa precursor	1.50
H15267	CHL1, neural cell adhesion molecule	1.10
AA521362	CR2 receptor	1.07
R00276	CD38 alt	0.83
W07099	NAGLU, N-acetylglucosaminidase, alpha	0.77
T49652	FLAP, ALOX5AP	0.77
AA044267	P2X5a	0.76
R40400	CHL1, neural cell adhesion molecule	0.75
H09567	PAG1	0.71
AI400399	CYP7B1	0.70
AA149640	FLT1	0.67
H17800	Unknown protein	0.67
H02307	FLAP, ALOX5AP	0.67
AA917693	Unknown protein	0.66
AI017382	ATXN7L1	0.66
AI091671	Unknown protein	0.65
N50114	PAG1	0.65
H95977	Nmd protein, PLA1A	0.65
AA040389	Unknown protein	0.64
H24011	Homeodomain-like protein	0.64
AI275120	Unknown protein	0.63
AA708955	SCHIP1, schwannomin interacting protein 1	0.62
AA406546	IL6ST, IL6 signal transducer, gp130	0.62
R79082	PTPRK	0.59
AI241341	CHL1, neural cell adhesion molecule	0.59
T61343	IL6ST, IL6 signal transducer, gp130	0.59
	Downregulated (log2(ratio) ≤ -0.58)
AA446027	EGR2, Krox-20 homolog	-0.90
AA630734	seryl-tRNA synthetase	-0.86
R47893	CCL3L1	-0.80
AA682565	Unknown protein from neuroblastoma	-0.76
R78530	COTL1	-0.73
AA933744	ECAT11	-0.73
N58443	GPR55	-0.68
H99699	mitochondrial aconitase	-0.64
H03494	CD44	-0.63
AA450353	ELMOD1	-0.63
AA458965	IL32, natural killer cell protein, transcript 4	-0.63
R33402	SAMSN1	-0.62
AA111969	CD83 antigen	-0.60
AI380522	ITGB7, integrin beta-7 subunit	-0.60
AA682637	CHST2	-0.59

*Mean log₂(ratio)of gene expression across 5 sets of twins with ASD. SAM analysis revealed 1281 significant genes with a median FDR of 15.6%. Only genes for which microarray data is available for all 3 sets of twins are included in this table. Genes in boldface type have been shown to be relevant to neurological development, structure, or function.

ISSN: 1471-2164