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Table 3 Pathogen-specific virulence genes absent in N. lactamica.

From: The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica, including those designated as 'virulence genes'

No hybridization on microarraya N. lactamica genome sequence resultsb Final results
ssa 1 Present, but divergent Present
pilC Present, but divergent Present
pilD Present, possibly divergent in strains tested Present
pglD Present, but divergent Present
pglF Present, possibly divergent in strains tested Present
dca/pptA Absent. The equivalent region contains an alternative hypothetical gene. Absent
ABC transport (NMB1880) Absent in genome sequence Absent
TonB-dependent receptor, NMB1882 Absent in genome sequence Absent
virG Absent. The equivalent region contains an alternative hypothetical gene. Absent
iga encoding IgA protease Absent in genome sequence Absent
hemolysin, NMB1646 Absent. The equivalent region contains alternative gene sequences. Absent
  1. aVirulence-associated genes that are present in all strains of the pathogenic Neisseria spp., but did not produce positive microarray hybridizations with N. lactamica.
  2. bApproximately half of these genes are present in the unpublished genome sequence of N. lactamica, where sequence divergence from the pathogenic sequence can be observed.
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BMC Genomics

ISSN: 1471-2164

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