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Table 1 Gene ontology classification of the HCC differentially expressed genes

From: Differentially profiling the low-expression transcriptomes of human hepatoma using a novel SSH/microarray approach

Up-regulated genes* Down-regulated genes* P-value  
Cell cycle 19 4 0.052
Regulation of apoptosis 8 1 0.121
Transcription & regulation of transcription 44 13 0.040
Signal transduction 48 24 0.777
Cell organizaiton & biogenesis 28 9 0.109
Purine & pyrimidine metabolism 80 26 0.009
Protein metabolism 89 27 0.002
Nuclear © 89 26 0.001
Chromosome © 8 3 0.432
Cytoskeleton © 18 5 0.128
Ubiquitin ligase complex © 7 1 0.170
Complement & coagulation cascades 0 11 0.000
Response to wounding 4 12 0.011
Defense response 16 24 0.000
Response to external biotic stimuli 10 15 0.007
Immune response 14 21 0.001
Cell ion homeostasis 1 5 0.021
Microsome © 2 6 0.442
Peroxisome © 1 4 0.051
Extra-cellular space © 4 15 0.000
  1. *Based on 360 and 202 informative up- and down-regulated genes identified using the SSH/microarray in HCC.
  2. © cellular components, based on 207 and 110 informative up- and down-regulated genes in human HCC, respectively.
  3. P value was determined by Fisher's exact test.