Figure 1

Classification of the LINE fusion types. LINE FUSION GENES were classified into three types. (Type I) Alternative promoter: the promoters of LINEs incorporated near the 5'UTR or into an intron of the gene can act as antisense (ASPs) or sense (SPs) promoters, producing chimeric transcripts different from those of that gene. (Type II) Alternative Poly A signal: LINEs with the poly A signal incorporated in the gene can affect the transcription process resulting in alternative transcripts. (Type III) Exonization: LINEs can be recognized as splicing sites (AG-GT) or intact exons by the spliceosome. LINE element is indicated by yellow box, exon by green box and 5'-3'UTR by blue box.