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Table 6 Stage-specific Expression of some of Chlamydiae-specific Proteins

From: BLAST screening of chlamydial genomes to identify signature proteins that are unique for the Chlamydiales, Chlamydiaceae, Chlamydophila and Chlamydia groups of species

Stage of Expression Chlamydiales-specific Proteins Chlamydiaceae-specific Proteins Chlamydia-specific Proteins Lost or Transferred Genes
I-Early (6–24 hpi)   CT233   
II-Midlate (12–24 hpi) CT053
CT635
CT289
CT671
CT360 CT550
  CT066
CT666
CT372
CT870
  
  CT273
CT667
CT377
CT871
  
  CT504
CT670
CT413
CT872
  
  CT590
CT734
CT618
CT874
  
   CT668   
III-Midlate (18–24 hpi)   CT142   CT049
   CT143   CT051
   CT681   
   CT713   
IV-Late (24–36 hpi) CT016 CT005
CT552
CT249 CT050
  CT017 CT046
CT565
  CT214
  CT181 CT080
CT578
CT694 CT702
  CT443 CT082
CT579
  
  CT546 CT083
CT620
  CT868
   CT147
CT695
  
   CT288
CT712
  
   CT365
CT848
  
   CT392
CT869
  
   CT442   
   CT444   
  1. The temporal expression patterns of these proteins is based upon the microarray analysis of Nicholson et al [63]. According to the microarray profiles, significant differences were seen in the expression pattern of genes for these proteins at 4 different time points (6–24 hours post infection, 12–24 h.p.i., 18–24 h.p.i., and 24–36 h.p.i.) which correspond to different phases of the chlamydial developmental cycle where key phenotypic changes take place. It is of interest that the majority of the temporally regulated Chlamydiales and Chlamydiaceae-specific genes are expressed between 12–24 h.p.i. and 24–36 h.p.i. Such coordinate regulation suggests they play essential roles during these phases of the chlamydial cell cycle. Other chlamydiae-specific proteins which are not listed in this Table were not found to show significant differences in their temporal expression in the study by Nicholson et al. [63]. Abbreviation; h.p.i., hours post infection.