Figure 4

Comparison of basal gene expression between the selected inbred mouse strains, regulated by administration in the locus ceruleus (LC) or ventral tegmental area (VTA) of the C57BL/6J mice [34]. A. Cluster of genes whose expression was different according to array analysis. Coloured rectangles represent expression levels of the gene indicated on the right. Intensity of the colour is proportional to the fold change as indicated on the bar below the cluster image. The selected genes were previously found to be regulated by opioid administration as described on the right, after chronic morphine administration (CM) and morphine withdrawal (MW), respectively. Directions of the changes are indicated by arrows: (↑) – up-regulation and (↓) – down-regulation. Relative expression levels were measured by MBEI method. B. Expression level of Gfap and Mtap2 in the striatum, obtained by microarray experiment. Putative short mRNA forms detected by microarray probe-sets (Gfap – 1440142_s_at, Mtap2 – 1440699_at) are presented below. The image displays signal intensity from individual array with emphasized mean value.