Table 1 Global regulators. The numbers in braces denote the percentage of genes in the category regulated by the TF. In bold are the functional categories, which are dominantly regulated by the respective TF. Functional categories are as follows: AA, Amino acid biosynthesis; CPRO, Cellular processes; CEN, Cell envelope; CIM, Central intermediary metabolism; DNA, DNA metabolism; ENER, Energy metabolism; FATE, Protein fate; MOB, Mobile and extrachromosomal element functions; Signal, Signal transduction; PUR, Purines, pyrimidines, nucleosides and nucleotides; REG; Regulatory functions; Transport, Transport and binding proteins.
Protein | Functional Category | Regulatory role | Family |
|---|---|---|---|
AbrB | AA (10.2); CPRO (16.3); REG (30.6); Transport (18.3) | Regulates the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation | AbrB |
CcpA | CPRO (6.6); ENER (33.9); REG (13.2); Signal (4.7); Transport (26.4) | Repression of the carbohydrate utilization genes; and in the positive regulation of genes involved in excretion of excess carbon. | LacI |
CodY | AA (22.5); MOB (12.5); REG (20.0); Transport (12.5) | Repression of genes induced as cells make the transition from rapid exponential growth to stationary phase and sporulation. | CodY |
ComK | AA (12.1); CEN (15.6); CPRO (13.9); DNA (7.8); ENER (7.8); FATE (6.0); PUR (7.8); REG (10.4); Transport (6.9). | Intermediate regulatory gene required for the expression of the late competence genes. | ComK |
SpoOA | CPRO (17.0); PUR (23.1); REG (18.2); Transport (7.3) | Initiation of sporulation (negative regulation of abrB, kinA, kinC, spo0A; positive regulation of spoIIA, spoIIE, spoIIG) | OmpR |
TnrA | CIM (18.5); ENER (18.5); Transport (25.9) | Regulates genes during nitrogen-limited growth | MerR |