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Table 3 The 62 iL3-up clusters (Table 1) showing the mean cluster fold change between iL3 and L1 stages, the most significant BLAST alignment and the GO slim terms, arranged by descending iL3 : L1 difference in expression.

From: A microarray analysis of gene expression in the free-living stages of the parasitic nematode Strongyloides ratti

Cluster Expression1 BLAST alignment2 E2 Accession number2 Gene ontology (GO) slim term3
      Process Function Component
SR00272 21.86 -4 - - -4 - -
SR02119 9.45 - - - - - -
SR01748 4.66 Ce5 hypo prot6: predicted 1.00E-13 Y25C1A.3 - - -
SR00222 4.46 - - - - - -
SR02762 4.29 Ce hypo prot: confirmed 5.00E-14 B0213.17 - - -
SR00107 3.97 Ce ITR-1 4.00E-28 F33D4.2f rhythmic behaviour, muscle contraction, defecation inositol-1-,4-,5-triphosphate receptor activity membrane, endoplasmic reticulum
SR01733 3.78 - - - - - -
SR00647 3.68 Ce PAT-10 1.00E-79 F54C1.7 - calcium ion binding -
SR02628 3.63 Ce tyrosine aminotransferase 6.00E-46 F42D1.2 L-phenylalanine catabolism, tyrosine catabolism tyrosine transaminase activity unknown
SR00369 3.60 Ce LGG-1 1.00E-58 C32D5.9 protein targeting tubulin binding plasma membrane
SR03050 3.51 Ss EST 9.00E-28 TBN95TM-SSR - - -
SR01141 3.46 Ce TTH-1 2.00E-25 F08F1.8 - - -
SR01368 3.34 Ce hypo prot: partially confirmed 2.00E-11 W06A7.3e - unknown -
SR01871 3.29 Ce VAP-1 6.00E-08 F11C7.3b unknown unknown endoplasmic reticulum
SR00762 3.20 Ce hypo prot: partially confirmed 5.00E-81 ZC8.4b - motor activity non-muscle myosin
SR01845 3.18 Mm hypo prot 1.00E-08 XP_358683 - - -
SR03037 3.16 Ce transthyretin-like family 3.00E-41 C40H1.5 - unknown -
SR01142 3.05 Ce LPD-5 9.00E-61 ZK973.10 embryogenesis and morphogenesis, larval development - -
SR02353 3.05 Ss cDNA 2.00E-05 TBN95TM-SSFH - - -
SR00386 3.00 - - - - - -
SR01720 2.93 Ce FRM-1 2.00E-17 ZK270.2d - - -
SR01943 2.87 Pt EST 4.00E-17 NK7 - - -
SR00001 2.83 Ss EST 2.00E-10 TBN95TM-SSR - - -
SR02086 2.77 Pt EST 6.00E-11 NK - - -
SR00424 2.73 - - - - - -
SR02886 2.71 Ce hypo prot: confirmed 3.00E-74 ZK1073.1 spermatogenesis, cell differentiation, negative regulation of cell growth unknown -
SR02990 2.68 Ov FAR-1 3.00E-15 F02A9.2 - - -
SR03016 2.64 Ce hypo prot: predicted 9.00E-05 R07H5.10 - - -
SR00448 2.60 Ce SKR-1 3.00E-63 F46A9.5 embryogenesis and morphogenesis, reproduction - -
SR00092 2.53 Ce hypo prot: partially confirmed 3.00E-08 F55F8.6 - - -
SR02874 2.50 Ss cDNA 4.00E-05 TBN95TM-SSFH - - -
SR00073 2.46 Ce hypo prot: confirmed 2.00E-26 Y43F8B.1a - - -
SR00604 2.46 Ce PAB-1 4.00E-15 Y106G6H.2a regulation of protein activity, epigenetic - -
SR01164 2.43 Ss EST 2.00E-06 TBN95TM-SSFH - - -
SR02266 2.39 Ce hypo prot: partially confirmed 2.00E-23 R02F2.8 - - -
SR00717 2.39 Ce ATP synthase complex 4.00E-72 R53.4 - - -
SR01779 2.36 Ce hypo prot: predicted 7.00E-17 M60.7 - - -
SR02390 2.36 - - - - - -
SR00889 2.34 Ce ASP-3 8.00E-76 H22K11.1 induction of non-apoptotic programmed cell death, proteolysis and peptidolysis aspartic-type endopeptidase activity lysosome
SR00607 2.34 Ce ASB-2 2.00E-99 F02E8.1 embryogenesis and morphogenesis - -
SR00704 2.29 Ce hypo prot: confirmed 5.00E-54 E04A4.7 - - -
SR01197 2.29 Ce pancreatic trypsin inhibitor 3.00E-11 W01F3.3 - - -
SR00813 2.29 Ce ZYX-1 2.00E-65 F42G4.3a cell adhesion, signal transduction, cell-cell signalling - integral to plasma membrane
SR01881 2.28 Ce hypo prot: partially confirmed 9.00E-52 Y40B10A.2 - - -
SR00998 2.27 Ce MLC-2 3.00E-91 C36E6.5 regulation of striated muscle contraction, regulation of muscle contraction structural constituent of muscle cytoskeleton
SR00241 2.27 Ce LEV-11 4.00E-114 Y105E8B.1a regulation of muscle contraction unknown cytoskeleton, cytoskeleton
SR00192 2.25 Ce neuroendocrine protein 7B2 1.00E-38 T03D8.3 - GTP binding, enzyme activator activity secretory vesicle
SR02882 2.25 Ce ALG-1 1.00E-93 F48F7.1 embryonic development, larval development unknown -
SR01335 2.22 Ce PAS-5 4.00E-18 F25H2.9 - - 26S proteasome
SR00164 2.21 Ce hypo prot: confirmed 3.00E-71 Y37D8A.14 - cytochrome-c oxidase activity, electron transporter activity -
SR00231 2.18 - - - - - -
SR00903 2.18 Ss EST 9.00E-78 TBN95TM-SSFH - - -
SR01737 2.17 Ss EST 6.00E-09 TBN95TM-SSFH - - -
SR02037 2.17 Ce IFB-1 8.00E-42 F10C1.2a - - lamin filament
SR02982 2.17 Ce hypo prot: partially confirmed 4.00E-38 Y105E8A.19 tyrosyl-tRNA aminoacylation, apoptosis, cell motility, protein biosynthesis tyrosine-tRNA ligase activity, signal transducer activity, interleukin-8 receptor binding soluble fraction
SR02952 2.16 Ce hypo prot: partially confirmed 3.00E-41 K07E1.1 - - -
SR00038 2.13 Ce UBQ-1 7.00E-26 F25B5.4a proteolysis and peptidolysis, protein metabolism - ribosome
SR02710 2.11 Ce hypo prot: predicted 7.00E-38 Y59A8B.23 protein amino acid phosphorylation, response to stress receptor signalling protein serine/threonine kinase activity, ATP binding -
SR00308 2.09 Ce EAT-6 4.00E-18 B0365.3 - sodium/potassium-exchanging ATPase activity membrane fraction
SR00918 2.09 Ce FTT-2 4.00E-13 F52D10.3a chromosome segregation, learning and/or memory, olfactory learning protein kinase C inhibitor activity -
SR00906 2.06 Ce hypo prot: partially confirmed 7.00E-84 Y53G8AR.3 - - -
  1. 1The mean cluster iL3 : L1 difference in expression.
  2. 2The most significant BLAST alignment for each cluster, the BLAST score, E, and GenBank accession number.
  3. 3Gene ontology slim term, [52].
  4. 4- = no alignment or assignment, as appropriate.
  5. 5 Ce, C. elegans; Mm, Mus musculus; Ov, Onchocerca volvulus; Pt, Parastrongyloides trichosuri; Ss, Strongyloides stercoralis.
  6. 6hypo prot – hypothetical protein; predicted – ORF predicted by GeneFinder in WormBase [53]; partially confirmed – partial sequence cloned; confirmed – full-length sequence cloned.
  7. 7NK, not known.