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Table 3 The 62 iL3-up clusters (Table 1) showing the mean cluster fold change between iL3 and L1 stages, the most significant BLAST alignment and the GO slim terms, arranged by descending iL3 : L1 difference in expression.

From: A microarray analysis of gene expression in the free-living stages of the parasitic nematode Strongyloides ratti

Cluster

Expression1

BLAST alignment2

E2

Accession number2

Gene ontology (GO) slim term3

     

Process

Function

Component

SR00272

21.86

-4

-

-

-4

-

-

SR02119

9.45

-

-

-

-

-

-

SR01748

4.66

Ce5 hypo prot6: predicted

1.00E-13

Y25C1A.3

-

-

-

SR00222

4.46

-

-

-

-

-

-

SR02762

4.29

Ce hypo prot: confirmed

5.00E-14

B0213.17

-

-

-

SR00107

3.97

Ce ITR-1

4.00E-28

F33D4.2f

rhythmic behaviour, muscle contraction, defecation

inositol-1-,4-,5-triphosphate receptor activity

membrane, endoplasmic reticulum

SR01733

3.78

-

-

-

-

-

-

SR00647

3.68

Ce PAT-10

1.00E-79

F54C1.7

-

calcium ion binding

-

SR02628

3.63

Ce tyrosine aminotransferase

6.00E-46

F42D1.2

L-phenylalanine catabolism, tyrosine catabolism

tyrosine transaminase activity

unknown

SR00369

3.60

Ce LGG-1

1.00E-58

C32D5.9

protein targeting

tubulin binding

plasma membrane

SR03050

3.51

Ss EST

9.00E-28

TBN95TM-SSR

-

-

-

SR01141

3.46

Ce TTH-1

2.00E-25

F08F1.8

-

-

-

SR01368

3.34

Ce hypo prot: partially confirmed

2.00E-11

W06A7.3e

-

unknown

-

SR01871

3.29

Ce VAP-1

6.00E-08

F11C7.3b

unknown

unknown

endoplasmic reticulum

SR00762

3.20

Ce hypo prot: partially confirmed

5.00E-81

ZC8.4b

-

motor activity

non-muscle myosin

SR01845

3.18

Mm hypo prot

1.00E-08

XP_358683

-

-

-

SR03037

3.16

Ce transthyretin-like family

3.00E-41

C40H1.5

-

unknown

-

SR01142

3.05

Ce LPD-5

9.00E-61

ZK973.10

embryogenesis and morphogenesis, larval development

-

-

SR02353

3.05

Ss cDNA

2.00E-05

TBN95TM-SSFH

-

-

-

SR00386

3.00

-

-

-

-

-

-

SR01720

2.93

Ce FRM-1

2.00E-17

ZK270.2d

-

-

-

SR01943

2.87

Pt EST

4.00E-17

NK7

-

-

-

SR00001

2.83

Ss EST

2.00E-10

TBN95TM-SSR

-

-

-

SR02086

2.77

Pt EST

6.00E-11

NK

-

-

-

SR00424

2.73

-

-

-

-

-

-

SR02886

2.71

Ce hypo prot: confirmed

3.00E-74

ZK1073.1

spermatogenesis, cell differentiation, negative regulation of cell growth

unknown

-

SR02990

2.68

Ov FAR-1

3.00E-15

F02A9.2

-

-

-

SR03016

2.64

Ce hypo prot: predicted

9.00E-05

R07H5.10

-

-

-

SR00448

2.60

Ce SKR-1

3.00E-63

F46A9.5

embryogenesis and morphogenesis, reproduction

-

-

SR00092

2.53

Ce hypo prot: partially confirmed

3.00E-08

F55F8.6

-

-

-

SR02874

2.50

Ss cDNA

4.00E-05

TBN95TM-SSFH

-

-

-

SR00073

2.46

Ce hypo prot: confirmed

2.00E-26

Y43F8B.1a

-

-

-

SR00604

2.46

Ce PAB-1

4.00E-15

Y106G6H.2a

regulation of protein activity, epigenetic

-

-

SR01164

2.43

Ss EST

2.00E-06

TBN95TM-SSFH

-

-

-

SR02266

2.39

Ce hypo prot: partially confirmed

2.00E-23

R02F2.8

-

-

-

SR00717

2.39

Ce ATP synthase complex

4.00E-72

R53.4

-

-

-

SR01779

2.36

Ce hypo prot: predicted

7.00E-17

M60.7

-

-

-

SR02390

2.36

-

-

-

-

-

-

SR00889

2.34

Ce ASP-3

8.00E-76

H22K11.1

induction of non-apoptotic programmed cell death, proteolysis and peptidolysis

aspartic-type endopeptidase activity

lysosome

SR00607

2.34

Ce ASB-2

2.00E-99

F02E8.1

embryogenesis and morphogenesis

-

-

SR00704

2.29

Ce hypo prot: confirmed

5.00E-54

E04A4.7

-

-

-

SR01197

2.29

Ce pancreatic trypsin inhibitor

3.00E-11

W01F3.3

-

-

-

SR00813

2.29

Ce ZYX-1

2.00E-65

F42G4.3a

cell adhesion, signal transduction, cell-cell signalling

-

integral to plasma membrane

SR01881

2.28

Ce hypo prot: partially confirmed

9.00E-52

Y40B10A.2

-

-

-

SR00998

2.27

Ce MLC-2

3.00E-91

C36E6.5

regulation of striated muscle contraction, regulation of muscle contraction

structural constituent of muscle

cytoskeleton

SR00241

2.27

Ce LEV-11

4.00E-114

Y105E8B.1a

regulation of muscle contraction

unknown

cytoskeleton, cytoskeleton

SR00192

2.25

Ce neuroendocrine protein 7B2

1.00E-38

T03D8.3

-

GTP binding, enzyme activator activity

secretory vesicle

SR02882

2.25

Ce ALG-1

1.00E-93

F48F7.1

embryonic development, larval development

unknown

-

SR01335

2.22

Ce PAS-5

4.00E-18

F25H2.9

-

-

26S proteasome

SR00164

2.21

Ce hypo prot: confirmed

3.00E-71

Y37D8A.14

-

cytochrome-c oxidase activity, electron transporter activity

-

SR00231

2.18

-

-

-

-

-

-

SR00903

2.18

Ss EST

9.00E-78

TBN95TM-SSFH

-

-

-

SR01737

2.17

Ss EST

6.00E-09

TBN95TM-SSFH

-

-

-

SR02037

2.17

Ce IFB-1

8.00E-42

F10C1.2a

-

-

lamin filament

SR02982

2.17

Ce hypo prot: partially confirmed

4.00E-38

Y105E8A.19

tyrosyl-tRNA aminoacylation, apoptosis, cell motility, protein biosynthesis

tyrosine-tRNA ligase activity, signal transducer activity, interleukin-8 receptor binding

soluble fraction

SR02952

2.16

Ce hypo prot: partially confirmed

3.00E-41

K07E1.1

-

-

-

SR00038

2.13

Ce UBQ-1

7.00E-26

F25B5.4a

proteolysis and peptidolysis, protein metabolism

-

ribosome

SR02710

2.11

Ce hypo prot: predicted

7.00E-38

Y59A8B.23

protein amino acid phosphorylation, response to stress

receptor signalling protein serine/threonine kinase activity, ATP binding

-

SR00308

2.09

Ce EAT-6

4.00E-18

B0365.3

-

sodium/potassium-exchanging ATPase activity

membrane fraction

SR00918

2.09

Ce FTT-2

4.00E-13

F52D10.3a

chromosome segregation, learning and/or memory, olfactory learning

protein kinase C inhibitor activity

-

SR00906

2.06

Ce hypo prot: partially confirmed

7.00E-84

Y53G8AR.3

-

-

-

  1. 1The mean cluster iL3 : L1 difference in expression.
  2. 2The most significant BLAST alignment for each cluster, the BLAST score, E, and GenBank accession number.
  3. 3Gene ontology slim term, [52].
  4. 4- = no alignment or assignment, as appropriate.
  5. 5 Ce, C. elegans; Mm, Mus musculus; Ov, Onchocerca volvulus; Pt, Parastrongyloides trichosuri; Ss, Strongyloides stercoralis.
  6. 6hypo prot – hypothetical protein; predicted – ORF predicted by GeneFinder in WormBase [53]; partially confirmed – partial sequence cloned; confirmed – full-length sequence cloned.
  7. 7NK, not known.