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Table 4 In situ localization of TRPC3, TRPC5 and TRPC6 transcripts in different mouse organs

From: Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains

tissue TRPC3 TRPC5 TRPC6
Skeletal muscle    
   • sarcolemma + neg. ±
   • sarcoplasmic reticulum neg. neg. neg.
   • myofibrils neg. neg. neg.
Heart    
   • cardiac muscle cells + neg. ±
   • blood vessel endothelium neg. neg. neg.
Aorta    
   • Tunica muscularis + + n. d.
   • endothelium + neg. n. d.
small intestine    
   • smooth muscle layer neg. ± neg.
   • submucosa + ± ±
   • enterocytes of the villi ++ + ++
   • enterocytes of the crypts +++ +++ ++
Kidney    
   • glomeruli ± neg. neg.
   • distal tubule +++ ± ++
   • proximal tubule neg. neg. neg.
Lung    
   • bronchial epithel +++ + ++
   • pneumocytes + ± +
   • blood vessel endothelium + neg. +
Liver    
   • hepatocytes +++ ++ ++
   • epithel of the Ductus interlobularis bilifer +++ ++ ++
Spleen    
   • red pulp ++ neg. neg.
   • white pulp neg. ++ ++
Pancreas    
   • exocrine acini +++ +++ +++
   • islet of Langerhan's neg. neg. neg.
   • duct system ++ neg. neg.
   • blood vessel endothelium neg. neg. neg.
testis    
   • leydig cells + + ++
   • sertoli cells neg. neg. neg.
   • spermatogonia/spermatocytes neg. neg. +
   • spermatozoa neg. neg. ++
Epididymis    
   • epithelium of the Ductuli efferentes testis +++ ++ ++
   • epithelium of the Ductus epididymidis + ++ ++
   • spermatozoa neg. neg. neg.
Uterus    
   • endometrium – glandular epithelial cells ++ +++ +++
   • myometrium neg. ++ +
fallopian tube    
   • smooth muscle layer neg. ± neg.
   • tubal epithelium + + +
Ovary    
   • cortex    
- granulosa cells ++ + ++
- theca cells neg. ± +
- corpus luteum neg. ± +
   • medulla neg. neg. +
CNS    
   • spinal ganglia +++ + n. d.
   • cortex ++ ± +
   • hippocampus + neg. +
   • ventricle ependym +++ ± ++
   • basal ganglia ++ neg. ++
   • cerebellum    
- Purkinje cells ++ ± +++
- Stratum granulosum + neg. +
  1. The in situ hybridization technique was applied to tissue sections as shown in Fig. 3. The obtained signals were classified into six categories: negative (neg.), very weak (±), weak (+), moderate (++), strong (+++) or not determined (n. d.).