Table 3 Groups of genes involved in liver processes that are affected by 5-aza-dC.

Xenobiotic Metabolism

ABHD6^

Hs.476454

221552_at

1.82

0.00394

0.12238

634

1151

Abhydrolase domain containing 6

AKR1C1^

Hs.460260

1555854_at

2.92

0.00027

0.04452

345

1007

Aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-a

CYP3A4^

Hs.442527

205999_x_at

1.78

0.01792

0.21785

370

660

Cytochrome P450, family 3, subfamily A, polypeptide 4

CYP3A5^

Hs.150276

214234_s_at

2.53

0.00159

0.08806

968

2447

Cytochrome P450, family 3, subfamily A, polypeptide 5

CYP3A7^

Hs.111944

211843_x_at

4.11

0.00387

0.12175

515

2120

Cytochrome P450, family 3, subfamily A, polypeptide 7

HAMP^

Hs.8821

220491_at

2.34

0.01066

0.17693

1076

2512

Hepcidin antimicrobial peptide

UGT1A6^

Hs.546397

215125_s_at

2.73

0.00318

0.11285

143

389

UDP glycosyltransferase 1 family, polypeptide A9

UGT2B15^

Hs.150207

207392_x_at

1.79

0.01965

0.22477

323

577

UDP glycosyltransferase 2 family, polypeptide B15

UGT2B28

Hs.137585

211682_x_at

-2.69

0.00131

0.08111

11036

4109

UDP glycosyltransferase 2 family, polypeptide B28

Steroid Biosynthesis

CYP17A1

Hs.438016

205502_at

1.92

0.00208

0.09647

325

622

Cytochrome P450, family 17, subfamily A, polypeptide 1

CYP19A1^

Hs.511367

203475_at

2.43

0.00356

0.11831

470

1144

Cytochrome P450, family 19, subfamily A, polypeptide 1

CYP51A1^

Hs.417077

202314_at

-1.31

0.00975

0.17073

11672

8910

Cytochrome P450, family 51, subfamily A, polypeptide 1

DHCR7^

Hs.503134

201791_s_at

-1.4

0.02202

0.23665

3628

2588

7-dehydrocholesterol reductase

FDFT1^

Hs.546253

208647_at

-1.37

0.00820

0.16076

24377

17858

Farnesyl-diphosphate farnesyltransferase 1

FDXR^

Hs.69745

207813_s_at

2.31

0.00046

0.05618

2066

4764

Ferredoxin reductase

HMGCR^

Hs.11899

202539_s_at

-1.34

0.03567

0.28427

10570

7864

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

HSD17B1^

Hs.500159

205829_at

6.02

0.00853

0.16330

157

944

Hydroxysteroid (17-beta) dehydrogenase 1

HSD17B2^

Hs.162795

204818_at

2.68

0.00198

0.09502

1818

4869

Hydroxysteroid (17-beta) dehydrogenase 2

LSS^

Hs.517366

202245_at

-1.32

0.00717

0.15151

5751

4356

Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)

PMVK

Hs.30954

203515_s_at

1.6

0.00661

0.14527

1046

1674

Phosphomevalonate kinase

RODH^

Hs.524513

37512_at

3.67

0.00046

0.05648

173

634

3-hydroxysteroid epimerase

SC5DL^

Hs.287749

211423_s_at

-1.19

0.01127

0.18081

10122

8494

Sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like

SQLE^

Hs.71465

209218_at

-1.32

0.00603

0.14008

16131

12229

Squalene epoxidase

STARD4^

Hs.93842

226390_at

-1.22

0.01833

0.21953

4385

3593

START domain containing 4, sterol regulated

CCAAT element binding proteins

CEBPA*^

Hs.76171

204039_at

1.69

0.00049

0.04052

3106

5262

CCAAT/enhancer binding protein (C/EBP), alpha

CEBPB^

Hs.517106

212501_at

-1.95

0.01864

0.22082

28789

14762

CCAAT/enhancer binding protein (C/EBP), beta

CEBPG^

Hs.429666

225527_at

-2.15

0.04308

0.30614

3734

1741

CCAAT/enhancer binding protein (C/EBP), gamma

CEBPZ*^

Hs.135406

203341_at

-1.34

0.00286

0.08197

4880

3655

CCAAT/enhancer binding protein zeta

CUTL1*^

Hs.438974

214743_at

-1.57

0.00957

0.1289

1672

1067

Cut-like 1, CCAAT displacement protein (Drosophila)

NFIC*^

Hs.170131

226895_at

1.23

0.01727

0.16248

1452

1786

Nuclear factor I/C (CCAAT-binding transcription factor)

NFYC^

Hs.233458

202215_s_at

1.38

0.01163

0.18301

1612

2228

Nuclear transcription factor Y, gamma