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Table 3 Groups of genes involved in liver processes that are affected by 5-aza-dC.

From: Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation

Gene Symbol Unigene Affymetrix ID Fold Change p-value FDR Control Signal 5-aza-dC Signal Description
Xenobiotic Metabolism
ABHD6^ Hs.476454 221552_at 1.82 0.00394 0.12238 634 1151 Abhydrolase domain containing 6
AKR1C1^ Hs.460260 1555854_at 2.92 0.00027 0.04452 345 1007 Aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-a
CYP3A4^ Hs.442527 205999_x_at 1.78 0.01792 0.21785 370 660 Cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5^ Hs.150276 214234_s_at 2.53 0.00159 0.08806 968 2447 Cytochrome P450, family 3, subfamily A, polypeptide 5
CYP3A7^ Hs.111944 211843_x_at 4.11 0.00387 0.12175 515 2120 Cytochrome P450, family 3, subfamily A, polypeptide 7
HAMP^ Hs.8821 220491_at 2.34 0.01066 0.17693 1076 2512 Hepcidin antimicrobial peptide
UGT1A6^ Hs.546397 215125_s_at 2.73 0.00318 0.11285 143 389 UDP glycosyltransferase 1 family, polypeptide A9
UGT2B15^ Hs.150207 207392_x_at 1.79 0.01965 0.22477 323 577 UDP glycosyltransferase 2 family, polypeptide B15
UGT2B28 Hs.137585 211682_x_at -2.69 0.00131 0.08111 11036 4109 UDP glycosyltransferase 2 family, polypeptide B28
Steroid Biosynthesis
CYP17A1 Hs.438016 205502_at 1.92 0.00208 0.09647 325 622 Cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1^ Hs.511367 203475_at 2.43 0.00356 0.11831 470 1144 Cytochrome P450, family 19, subfamily A, polypeptide 1
CYP51A1^ Hs.417077 202314_at -1.31 0.00975 0.17073 11672 8910 Cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR7^ Hs.503134 201791_s_at -1.4 0.02202 0.23665 3628 2588 7-dehydrocholesterol reductase
FDFT1^ Hs.546253 208647_at -1.37 0.00820 0.16076 24377 17858 Farnesyl-diphosphate farnesyltransferase 1
FDXR^ Hs.69745 207813_s_at 2.31 0.00046 0.05618 2066 4764 Ferredoxin reductase
HMGCR^ Hs.11899 202539_s_at -1.34 0.03567 0.28427 10570 7864 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
HSD17B1^ Hs.500159 205829_at 6.02 0.00853 0.16330 157 944 Hydroxysteroid (17-beta) dehydrogenase 1
HSD17B2^ Hs.162795 204818_at 2.68 0.00198 0.09502 1818 4869 Hydroxysteroid (17-beta) dehydrogenase 2
LSS^ Hs.517366 202245_at -1.32 0.00717 0.15151 5751 4356 Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
PMVK Hs.30954 203515_s_at 1.6 0.00661 0.14527 1046 1674 Phosphomevalonate kinase
RODH^ Hs.524513 37512_at 3.67 0.00046 0.05648 173 634 3-hydroxysteroid epimerase
SC5DL^ Hs.287749 211423_s_at -1.19 0.01127 0.18081 10122 8494 Sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like
SQLE^ Hs.71465 209218_at -1.32 0.00603 0.14008 16131 12229 Squalene epoxidase
STARD4^ Hs.93842 226390_at -1.22 0.01833 0.21953 4385 3593 START domain containing 4, sterol regulated
CCAAT element binding proteins
CEBPA*^ Hs.76171 204039_at 1.69 0.00049 0.04052 3106 5262 CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB^ Hs.517106 212501_at -1.95 0.01864 0.22082 28789 14762 CCAAT/enhancer binding protein (C/EBP), beta
CEBPG^ Hs.429666 225527_at -2.15 0.04308 0.30614 3734 1741 CCAAT/enhancer binding protein (C/EBP), gamma
CEBPZ*^ Hs.135406 203341_at -1.34 0.00286 0.08197 4880 3655 CCAAT/enhancer binding protein zeta
CUTL1*^ Hs.438974 214743_at -1.57 0.00957 0.1289 1672 1067 Cut-like 1, CCAAT displacement protein (Drosophila)
NFIC*^ Hs.170131 226895_at 1.23 0.01727 0.16248 1452 1786 Nuclear factor I/C (CCAAT-binding transcription factor)
NFYC^ Hs.233458 202215_s_at 1.38 0.01163 0.18301 1612 2228 Nuclear transcription factor Y, gamma
  1. * = Genes that are only significantly affected by both 5-aza-dC and TSA.
  2. ^ = Expressed in fetal and/or adult liver.