Table 3 List of tags with significant variation in expression level induced by UN injection (p < 0.05). The table includes their frequency and their relevant accession number.
From: Comprehensive analysis of the renal transcriptional response to acute uranyl nitrate exposure
Tag sequence | Count | Gene name | Accession No. | Regulation (up: +, down: -) | Gene symbol | |
| Â | UN- | UN+ | Â | Â | Â | Â |
Apoptosis | ||||||
TGACACAGGA | 4 | 0 | cell death-inducing DNA fragmentation factor, alpha subunit-like effector B | NM_009894 | - | Cideb |
TAGGGCAATC | 2 | 12 | SMT3 (supressor of mif two, 3) homolog 2, pseudogene 4 | Â | + | Smt3 h2-ps4 |
Amino acid metabolism | ||||||
ATTAACTTGG | 4 | 16 | glutamate dehydrogenase | NM_008133 | + | Glud |
ATACTAACGT | 53 | 14 | ornithine decarboxylase, structural | NM_013614 | - | Odc |
Carbohydrate metabolism | ||||||
TGGATGCCTT | 7 | 1 | alcohol dehydrogenase 1, complex | NM_007409 | - | Adh1 |
TGGATCTCTG | 5 | 0 | carbonic anhydrase 4 | NM_007607 | - | Car4 |
CTATAATGCC | 25 | 8 | fructose bisphosphatase 1 | NM_019395 | - | Fbp1 |
TTGTTCTGAC | 0 | 6 | glucose phosphate isomerase 1 complex | NM_008155 | + | Gpi |
CAGTTTGTAA | 4 | 0 | pyruvate dehydrogenase E1 alpha 1 | NM_008810 | - | Pdaha 1 |
ATAAGGGATT | 0 | 6 | UDP-galactose translocator 2 | NM_016752 | + | Ugalt2 |
Cell adhesion | ||||||
GAAGAAAGGG | 10 | 1 | platelet/endothelial cell adhesion molecule | NM_008816 | - | Pecam |
Cell cycle/mitosis | ||||||
GCGAGGGAGC | 4 | 0 | dim1 (S. pombe) | NM_025299 | - | Dim-pending |
TGCTGCCATT | 0 | 6 | tubulin alpha 6 | NM_009448 | + | Tuba6 |
Homeostasis | ||||||
CCCTGGGTTC | 32 | 62 | ferritin light chain 1 | NM_010240 | + | Ftl1 |
Immunity and defense | ||||||
Immunity | ||||||
TTATGGAAT | 0 | 7 | CD24a antigen | NM_009846 | + | Cd24a |
GTTCAAGTGA | 1 | 9 | Ia-associated invariant chain Ag CD74 classe II | NM_010545 | + | Ii/CD74 |
TAGGGAATGG | 0 | 5 | interferon-induced protein with tetratricopeptide repeats 3 | NM_010501 | + | Ifit3 |
CTGAGAGATA | 1 | 13 | lectin, galactose binding, soluble 3 | NM_010705 | + | Lgals3/Gal-3 |
ATTGGGGGAG | 6 | 18 | osteoclast inhibitory lectin | NM_053109 | + | ocil-pending |
CAAACACCGT | 7 | 104 | secreted phosphoprotein 1 | NM_009263 | + | Spp1, Opn |
TGGGTTGTCT | 149 | 263 | translationally regulated transcript (21 kDa), | NM_009429 | + | Trt, Tpt1, Tctp |
TTTTATGTTT | 12 | 21 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | NM_009395 | + | Tnfaip1 |
TATACATCCA | 23 | 69 | uromodulin | NM_009470 | + | Umod |
Antioxidant and free radical removal | ||||||
CTATCCTCTC | 419 | 537 | glutathione peroxidase 3 | NM_008161 | + | Gpx3 |
ATGTGGTGTG | 29 | 15 | peroxiredoxin 1 | NM_011034 | - | Prdx1 |
GGTGAGCCTG | 1 | 8 | peroxiredoxin 2 | NM_011563 | + | Prdx2 |
TATCTGTGCA | 28 | 16 | selenoprotein P, plasma, 1 | NM_009155 | - | Sepp 1 |
AGAAACAAGA | 19 | 6 | superoxide dismutase 1, soluble | XM_128337 | - | Sod1 |
TTGCTTCTAT | 12 | 0 | thioether S-methyltransferase | NM_009349 | - | Temt |
CTACGTTCTC | 2 | 9 | thioredoxin-like 2 | NM_023140 | + | Txnl2 |
Lipid fatty acid and steroid metabolism | ||||||
AGCCCTCGGA | 5 | 0 | acetyl-Coenzyme A dehydrogenase, short chain | NM_007383 | - | Acads |
TTAAGACCTG | 10 | 21 | crystallin, zeta | NM_009968 | + | CryZ |
TAGAATAAAC | 4 | 0 | cytochrome P450, 2d9 | NM_080006 | - | Cyp2d9 |
TGTGTGGAAT | 16 | 7 | cytochrome P450, subfamily IV B, polypeptide 1 | NM_007823 | - | Cyp4b1 |
TGCCAACGCA | 25 | 10 | hydroxysteroid dehydrogenase-4 | NM_008292 | - | Hsd17b4 |
AATTTAATTA | 5 | 0 | phytanoyl-CoA hydroxylase | NM_010726 | - | Phyh |
Muscle contraction | ||||||
TGCAGTCATC | 8 | 1 | transgelin | NM_011526 | - | Tagln |
CTCTGGGGCT | 0 | 6 | transgelin 2 | NM_178598 | + | Tagln2 |
Nucleoside, nucleotide and nucleic acid metabolism | ||||||
CTAGATTGCG | 4 | 0 | ectonucleoside triphosphate diphosphohydrolase 5 | NM_007647 | - | Entpd5 |
AAGAAACCAG | 33 | 16 | expressed in non-metastatic cells 2, protein (NM23B) (nucleoside diphosphate kinase) | NM_008705 | - | Nme2 |
GTGTAATAAG | 2 | 8 | heterogeneous nuclear ribonucleoprotein A2/B1 | NM_016806 | + | Hnrpa2b1 |
GGGAGCGAAA | 16 | 8 | inhibitor of DNA binding 2 | NM_010496 | - | Idb2 |
TACTGTCCTG | 5 | 0 | RNA polymerase 1–3 (16 kDa subunit) | NM_009087 | - | Rpo1–3 |
Oxydoreductase | ||||||
AATGGCTAGC | 13 | 5 | cytochrome c, somatic | NM_025567 | - | Cycs |
Protein metabolism and modification | ||||||
Amino acid activation | ||||||
GCCAATAGTG | 0 | 5 | endothelial monocyte activating polypeptide 2 | NM_007926 | - | Emap2/Scye1 |
Protein biosynthesis | ||||||
TCACCCAATA | 64 | 44 | eukaryotic translation elongation factor 2 | NM_007907 | - | Eef2 |
CTAATAAAGC | 34 | 68 | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived) | NM_007990 | + | Fau |
AGATCTATAC | 13 | 4 | ribosomal protein L7 | NM_011291 | - | Rpl7 |
AACAATTTG | 21 | 52 | ribosomal protein L9 | NM_011292 | + | Rpl9 |
GGCAAGCCCC | 20 | 42 | ribosomal protein L10A | NM_011287 | + | Rpl10a |
TGGATCAGTC | 77 | 131 | ribosomal protein L19 | NM_009078 | + | Rpl19 |
ATTCTCCAGT | 13 | 36 | ribosomal protein L23 | NM_022891 | + | Rpl23 |
CCCACAAGGT | 16 | 6 | ribosomal protein L27 | NM_011289 | - | Rpl27 |
GGCTTCGGTC | 55 | 124 | ribosomal protein, large, P1 | NM_018853 | + | Rplp1 |
TGTAGTGTAA | 26 | 52 | ribosomal protein S8 | NM_009098 | + | Rps8 |
TGGCCCAAA | 2 | 12 | ribosomal protein S16 | NM_013647 | + | Rps16 |
GCCTTTATGA | 24 | 14 | ribosomal protein S24 | NM_011297 | + | Rps24 |
TAAAGAGGCC | 21 | 48 | ribosomal protein S26 | NM_013765 | + | Rps26 |
CTAGTCTTTG | 35 | 81 | ribosomal protein S29 | NM_009093 | + | Rps29 |
Protein folding | ||||||
TAACAGTTGT | 5 | 16 | calnexin | NM_007597 | + | Canx |
GATTGTCAAA | 1 | 11 | FK506 binding protein 3 (25 kD) | NM_013902 | + | Fkbp3 |
AGAGTTCAGA | 13 | 4 | heat shock protein, 60 kDa | NM_010477 | - | Hspd1/Hsp60 |
GAATAATAAA | 52 | 29 | heat shock 70 kD protein 8 | NM_031165 | - | Hspa8/Hsp73 |
Proteolysis | ||||||
CCTTGCTCAA | 11 | 27 | cystatin C | NM_009976 | + | Cst3 |
GAGAGTGTGA | 13 | 5 | kidney-derived aspartic protease-like protein | NM_008437 | - | Kdap |
ACCATTATAA | 14 | 7 | lysosomal membrane glycoprotein 2 | NM_010685 | - | Lamp2 |
TAGCTTCCTC | 15 | 37 | sequestosome 1 | NM_011018 | + | Sqstm1/p62 |
TGACCCCGGG | 51 | 88 | ubiquitin A-52 residue ribosomal protein fusion product 1 | NM_019883 | + | Uba52 |
CAGATCTTTG | 6 | 19 | ubiquitin C | NM_145578 | + | Ubc |
Translation regulation | ||||||
TGAAATACTT | 31 | 15 | heat-responsive protein 12 | NM_008287 | - | Hrsp12 |
Signal transduction system, receptor | ||||||
GCACAACTTG | 3 | 15 | calmodulin 2 | NM_007589 | + | Calm2 |
GGCTGTTGAA | 0 | 10 | cysteine rich protein | NM_007791 | + | csrp1 |
CATACGCATA | 15 | 3 | growth hormone receptor | NM_010284 | - | Ghr |
GCTGCAGTTG | 0 | 5 | guanine nucleotide binding protein, beta 2, related sequence 1 | NM_008143 | + | Gnb2-rs1 |
AGAGACAAGG | 23 | 4 | N-myc downstream regulated 1 | NM_006096 | - | Ndrg1 |
ATCTCCTAGC | 0 | 10 | matrix gamma-carboxyglutamate (gla) protein | NM_008597 | + | Mglap |
AGCACTTTGC | 1 | 10 | Mus musculus, serine threonine kinase pim3, clone MGC:27707 IMAGE:4924687 | Â | Â | + |
GGCAGATGGA | 17 | 8 | parathyroid hormone receptor, PTH R | NM_011199 | - | Pthr |
TGGGGAAGAG | 1 | 8 | phosphatidylethanolamine binding protein | NM_018858 | + | Pbp |
TAACCAATCA | 7 | 19 | RAB5C | NM_004583 | + | Rab5c |
AAAATTGCTT | 14 | 0 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | NM_011740 | - | Ywhaz |
Transport | ||||||
Electron transport | ||||||
GCTTTGAATG | 40 | 19 | ATPase inhibitor | NM_007512 | - | Atpi |
GAAGGAAACC | 4 | 0 | ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit | NM_016774 | - | Atp5b |
GCATACGGC | 5 | 12 | ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit e | NM_007507 | + | Atp5k |
TTATGAAATG | 31 | 58 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 | NM_019443 | + | Ndufa1 |
CTTGCAAGTG | 40 | 26 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9 | NM_023172 | - | Ndufb9 |
Ion transport | ||||||
ATGGGATTGA | 0 | 21 | glutamate receptor, ionotropic, kainate 1 | NM_146072 | + | Grik1 |
AGAGGCTACA | 4 | 0 | solute carrier family 21 (organic anion transporter)mb1 | NM_013797 | - | Slc21a1 |
GACACATACC | 57 | 23 | solute carrier family 22 (organic cation transporter)-like 2 | NM_009203 | - | Slc22al2 |
ACATTTCCAG | 5 | 0 | solute carrier family 27 (fatty acid transporter), mb 2 | NM_011978 | - | Slc27a2 |
TTGTGAGCCA | 23 | 8 | solute carrier family 34 (sodium phosphate), member 1 | NM_011392 | - | Slc34a1 |
Lipid and fatty acid transport | ||||||
GCTCTGATAC | 5 | 0 | sterol carrier protein 2, liver | NM_138508 | - | Scp2 |
Others | ||||||
GAACCTCTCC | 0 | 5 | amyotrophic lateral sclerosis 2 (juvenile) homolog (human) | NM_028717 | + | Als2 |
GAAGATCTAA | 5 | 0 | DNA segment, Chr 10, Johns Hopkins University 81 expressed | NM_138601 | - | D10jhu81e |
GTCGTGCCAT | 59 | 12 | DNA segment, Chr 7, Roswell Park 2 complex, expressed | NM_033080 | - | D7rp2e |
TCATTCTCCA | 9 | 0 | erythrocyte protein band 4.1-like 4a | NM_013512 | - | Epb4.1l4a |
CTCCTGCAGC | 18 | 41 | esterase 10 | NM_016903 | + | Es10 |
CTTCTTTCTG | 0 | 7 | growth arrest specific 6 | NM_019521 | + | Gas6 |
TAGCTTTAAA | 45 | 85 | insulin-like growth factor binding protein 7 | NM_008048 | + | Igfbp7 |
GACTTCACGC | 283 | 91 | kidney androgen regulated protein | NM_010594 | - | Kap |
GCATAGAAAT | 22 | 8 | kidney-specific membrane protein | NM_020626 | - | Nx17-pending |
TAACTGACAA | 4 | 20 | metallothionein 2 | NM_008630 | + | Mt2 |
TGACCACGGG | 1 | 9 | myeloid differentiation primary response gene 88 | NM_010851 | + | Myd88 |
GCCCCAATAA | 20 | 12 | phosphatidylcholine transfer protein-like | NM_019990 | - | Pctpl/Sdccagg28 |
TAATACTCAA | 73 | 49 | upregulated during skeletal muscle growth 5 | NM_023211 | - | Usmg5 |