Table 3 Takifugu rubripes protein genes under positive Darwinian selection with significantly lower (^a) or higher (^b) distance to the human ortholog than other fish species. Duplicated genes are given with rate differences between the two copies according to the relative rate test of Tajima (1993) at the 5% level with one asterisk and at the 1% level with two asterisks.

FRUP00000147506

syntaxin 3A ^a

0.178**

FRUP00000132184

lysyl oxidase-like 1 ^a

0.207**

FRUP00000139282

chloride intracellular channel 5 ^a

0.074

FRUP00000156028

twisted gastrulation ^a

-

FRUP00000136434

mitochondrial elongation factor G1 ^a

0.170*

FRUP00000139600

TAFA2 ^a

-

FRUP00000129212

serine/threonine protein kinase 6 ^a

-

FRUP00000153498

exostosin 1 ^a

0.086

FRUP00000133663

zinc finger protein 106 homolog ^b

0.201**

FRUP00000162759

hydroxysteroid (17-beta) dehydrogenase 4 ^a

-

FRUP00000133083

dUTP pyrophosphatase ^a

-

FRUP00000133686

excision repair cross-complementing 1 isoform 2 ^a

-

FRUP00000132409

cytochrome c oxidase subunit Va ^a

-

FRUP00000129950

glycine cleavage system protein H ^a

-

FRUP00000140923

mitogen-activated protein kinase kinase kinase kinase 2 ^a

-

FRUP00000157532

tryptophan rich basic protein ^a

-

FRUP00000133839

stress-induced-phosphoprotein 1 ^a

-

FRUP00000136741

dual specificity phosphatase 14 ^a

-

FRUP00000148346

transitional epithelia response protein ^a

-

FRUP00000149078

drebrin-like ^a

-

FRUP00000151439

jumonji domain containing 2C ^a

0.319**

FRUP00000134740

tumor necrosis factor type 1 receptor associated protein ^a

0.099**

FRUP00000133087

leprecan-like 1 ^a

0.317**

FRUP00000144902

calcium binding protein 5 ^a

0.012

FRUP00000162608

neurogenic differentiation 4 ^a

-

FRUP00000130779

FLJ21963 protein ^a

-

FRUP00000143840

thioredoxin domain containing ^a

-

FRUP00000154905

terminal deoxynucleotidyltransferase interacting factor 1 ^a

-

FRUP00000128255

SMILE protein ^a

-