Table 4 Danio rerio genes under positive Darwinian selection with significantly lower (^a) or higher (^b) distance to the human ortholog than other fish species. Duplicated genes are given with rate differences between the two copies according to the relative rate test of Tajima (1993) at the 5% level with one asterisk and at the 1% level with two asterisks. Known gene symbols according to ZFIN are also provided.

ENSDARP00000003385

ankyrin repeat domain 28 ^a

0.285**

ENSDARP00000024204

vesicle-associated membrane protein A isoform 2 ^a

-

ENSDARP00000006783

cofilin 2 ^a

0.078*

ENSDARP00000026380

KIAA0073 protein ^a

-

ENSDARP00000039499

haloacid dehalogenase-like hydrolase domain containing 2 ^a

-

ENSDARP00000005886

arsenate resistance protein ARS2 isoform b ^a

-

ENSDARP00000049098

thyroid hormone receptor interactor 13 ^a

-

ENSDARP00000010419

DnaJ subfamily A member 2 ^a

0.135

ENSDARP00000048880

gamma-glutamyl Carboxylase ^a

-

ENSDARP00000025803

SEC14 (S. cerevisiae)-like 1 ^a

0.114

ENSDARP00000001039

hypothetical protein MGC10882 ^a

-

ENSDARP00000038616

glutaryl-Coenzyme A dehydrogenase isoform a precursor ^a

0.083

ENSDARP00000024124

activin A type II receptor precursor ^a

0.057**

ENSDARP00000025487

DKFZP434B168 ^a

-

ENSDARP00000024082

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP ^a

-

ENSDARP00000038219

roundabout 1 isoform a ^a

0.276*

ENSDARP00000008117

HIRA interacting protein 5 ^a

-

ENSDARP00000026984

beta catenin-like 1 ^a

-

ENSDARP00000046992

carbohydrate (chondroitin) synthase 1 ^a

-

ENSDARP00000016016

phosphatidylserine decarboxylase ^a

-

ENSDARP00000023471

ADP-ribosylation factor-like 6 interacting protein ^a

-

ENSDARP00000002978

aspartate aminotransferase 1 ^a

0.015**

ENSDARP00000016111

ADP-ribosylation factor 4-like ^a

0.032**

ENSDARP00000018086

androgen-induced 1 ^a

-

ENSDARP00000015026

signal recognition particle 72 kDa ^a

-

ENSDARP00000038278

cytidine deaminase ^a

-

ENSDARP00000006977

ankyrin repeat domain 10 ^b

0.211

ENSDARP00000009789

chromobox homolog 3 HP1 gamma ^a

0.009**

ENSDARP00000016540

RAB25 ^a

0.170*