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Table 1 The asymmetry pattern of A↔G and C↔T iSNPs and FFD SNPs

From: Strand bias in complementary single-nucleotide polymorphisms of transcribed human sequences: evidence for functional effects of synonymous polymorphisms

Substitution type A→G T→C G→A C→T Total
iSNP      
Non-CpG site 1411 (19.5%) 1030 (14.2%) 1200 (16.6%) 1052 (14.5%) 4693 (64.8%)
CpG site 678 (9.4%) 561 (7.8%) 664 (9.2%) 643 (8.9%) 2546 (35.3%)
Non-CpG vs. CpG* χ2 = 3.2, v = 1, p = 0.074 χ2 = 2.1, v = 1, p = 0.151  
Total 2089 (28.9%) 1591 (22.0%) 1864 (25.8%) 1695 (23.4%) 7239 (100%)
FFD SNPs      
Non-CpG site 148(6.2%) 127(5.3%) 207(8.7%) 307(12.9%) 789(33.2%)
CpG site 316(13.3%) 163(6.9%) 654(27.5%) 452(19.0%) 1585(66.8%)
Non-CpG vs. CpG* χ2 = 10.9, v = 1, p = 0.001 χ2 = 50.1, v = 1, p < 0.001  
Total 464(19.5%) 290(12.2%) 861(36.3%) 759(32.0%) 2374(100.0%)
  1. * χ2 test of the difference of complementary substitution between non-CpG site and CpG site.