Genome sequence alterations detected upon passage of Burkholderia mallei ATCC 23344 in culture and in mammalian hosts

Table 5 Expression profile of the unpassaged reference strain (ATCC 23344) relative to the human liver isolate (JHU), expressed as the log₂ ratio of intensities.

Ratio	Locus	Annotation
1.82	BMAA0090	lipoprotein, putative
1.81	BMA3047	heat shock protein, Hsp20 family
1.79	BMAA0446	Rhs element Vgr protein
1.68	BMA3048	heat shock protein, Hsp20 family
1.46	BMA2461	C4-dicarboxylate transport protein
1.24	BMA0118	RNA polymerase sigma factor RpoD, putative
1.22	BMAA0922	drug resistance transporter, EmrB/QacA family
1.19	BMAA0618	hypothetical protein
1.18	BMAA1865	conserved hypothetical protein
1.16	BMA2979	acyltransferase family protein
1.15	BMA0017	hypothetical protein
1.14	BMA3164	hypothetical protein
1.11	BMAA2014	hypothetical protein
1.06	BMAA1384	hypothetical protein
1.06	BMA2875	hypothetical protein
1.04	BMA0361	thioredoxin, authentic frameshift
1.01	BMA0859	hypothetical protein
-1.02	BMAA0427	TonB-dependent copper receptor
-1.04	BMA0665	phosphoadenosine phosphosulfate reductase, putative
-1.07	BMAA1196	transcriptional regulator, LysR family

Genes exhibiting ≥ 2-fold intensity (mRNA abundance) difference are listed. Loci in bold type are also differentially expressed in the human blood isolate (FMH) (see Table 4).

ISSN: 1471-2164