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Table 3 Multivariate analysis of mortality and DMFP risk factors and BCMP11/ABCC11.

From: Discovery and validation of breast cancer subtypes

  Overall survival Distant metastasis-free probability
  Hazard ratio (95% confidence interval) p-value Hazard ratio (95% confidence interval) p-value
BCMP11/ABCC11: Group 2 vs. Group 1 2.124 (1.0923 – 4.130) 0.0260 1.759 (0.948 – 3.263) 0.073
BCMP11/ABCC11: Group 3 vs. Group 1 2.155 (1.1874 – 3.913) 0.0120 1.452 (0.817 – 2.580) 0.200
Age (decade) 0.688 (0.4792 – 0.988) 0.0430 0.736 (0.523 – 1.035) 0.078
Tumor diameter (cm) 1.022 (0.9967 – 1.048) 0.0890 1.034 (1.010 – 1.058) 0.006
Lymph node status (positive node) 1.010 (0.8309 – 1.228) 0.9200 1.045 (0.886 – 1.234) 0.600
Tumor grade: Poorly diff. vs. Intermediate 1.185 (0.6586 – 2.131) 0.5700 0.979 (0.560 – 1.713) 0.940
Tumor grade: Well diff. vs. Intermediate 0.240 (0.0828 – 0.698) 0.0088 0.403 (0.190 – 0.855) 0.018
Vascular invasion: 1–3 vessels vs. ≥ 4 vessels 0.627 (0.2150 – 1.829) 0.3900 0.530 (0.198 – 1.424) 0.210
Vascular invasion: 0 vessels vs. ≥ 4 vessels 0.589 (0.1322 – 2.621) 0.4900 0.560 (0.145 – 2.158) 0.400
Mastectomy vs. breast conserving therapy 1.119 (0.6933 – 1.807) 0.6400 1.193 (0.750 – 1.895) 0.460
Chemo and hormonal therapy v. no adjuvant therapy 0.724 (0.3281 – 0.1596) 0.4200 0.502 (0.246 – 1.022) 0.057
  1. Results of the multivariate analysis of mortality risk factors (left) and DMFP risk factors (right). The group classifications determined by the BCMP11 and ABCC11 gene pair are included. The p-values less than 0.05 are in bold. The p-values significant at an α = 0.10 level but not at an α = 0.05 significance level are in italics.