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Table 3 Perturbation of TFBSs by cis-SNPs and summary gene counts where TFBS predictions are affected by cis-SNPs

From: Cis-regulatory variations: A study of SNPs around genes showing cis-linkage in segregating mouse populations

Region

Total Genes Containing SNPs

CEGs Containing SNPs

Total Genes with TFBS Score Changed by SNPs

CEGs with TFBS Score Changed by SNPs

P-value (FET)

NCR

3514

1769

610

344

4.23E-04

Prom 2 Kb

1569

863

94

61

0.0174

Prom 5 Kb

2260

1220

193

111

0.1346

Cons NCR

1476

782

129

66

0.6338

Cons Prom 2 Kb

236

122

12

8

0.0852

Cons Prom 5 Kb

388

196

27

15

0.2293

  1. The total gene-set consisted of the combined set of CEGs and non-CEGs as described in the text. All p-values are based on the Fisher exact test (FET); p-values less than 0.01 are in bold.