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Table 1 Effect of hub disruptions on transcriptional regulatory network topology.

From: Effect of random and hub gene disruptions on environmental and mutational robustness in Escherichia coli

Disruption Connections lost1 Average pair-wise network distance2
Reference - 3.965
crp 283 4.480
dps 3 2 3.968
fis 152 4.040
relA &spoT 66 4.001
rpoS 40 4.017
  1. 1 Calculated as the total number of interactions the gene is involved in using the database of regulatory interactions described in Salgado et al (2006) [16]. See also note 3.
  2. 2 Calculated as the average pair-wise number of interactions separating all possible pairs of nodes using Pajek network analysis program [42].
  3. 3 The Dps protein affects gene expression, mediating changes in about 10% of 300–400 detected proteins [39-40]. Moreover, Dps is involved in massive and non-random reorganization of bacterial nucleoid during stationary phase, leading to global changes in gene expression. The indirect nature of these changes means that analysis of regulatory targets is not readily amenable to conventional computational analysis.