Table 3 Biological processes significantly affected (Fisher exact test p value < 0.05) by BaP in HepG2 cells as determined by EASE
HepG2 time and concentration down-regulated genes | HepG2 time and concentration up-regulated genes | ||
|---|---|---|---|
Biological Process | Probability | Biological Procees | Probability |
nucleosome assembly | 2.0E-04 | nucleosome assembly | 4.5E-04 |
establishment and/or maintenance of chromatin architecture | 4.7E-04 | prostaglandin metabolism | 6.9E-04 |
DNA packaging | 6.4E-04 | prostanoid metabolism | 6.9E-04 |
chromosome organization and biogenesis (sensu Eukarya) | 9.7E-04 | establishment and/or maintenance of chromatin architecture | 1.3E-03 |
nuclear organization and biogenesis | 1.0E-03 | DNA packaging | 1.8E-03 |
chromatin assembly/disassembly | 1.1E-03 | chromatin assembly/disassembly | 2.4E-03 |
complement activation, classical pathway | 4.5E-03 | chromosome organization and biogenesis (sensu Eukarya) | 2.7E-03 |
complement activation | 6.0E-03 | nuclear organization and biogenesis | 2.9E-03 |
vacuolar protein catabolism | 7.8E-03 | icosanoid metabolism | 3.3E-03 |
DNA metabolism | 9.5E-03 | blood coagulation | 3.6E-03 |
blood coagulation | 2.3E-02 | hemostasis | 4.5E-03 |
transcription from Pol II promoter | 2.7E-02 | glucuronate metabolism | 5.1E-03 |
hemostasis | 2.7E-02 | uronic acid metabolism | 5.1E-03 |
morphogenesis | 3.6E-02 | UDP-glucuronate biosynthesis | 5.1E-03 |
humoral defense mechanism (sensu Vertebrata) | 3.7E-02 | glucuronate biosynthesis | 5.1E-03 |
FGF receptor signaling pathway | 3.8E-02 | UDP-glucuronate metabolism | 5.1E-03 |
skeletal development | 4.7E-02 | obsolete biological process | 5.3E-03 |
| Â | Â | DNA metabolism | 7.1E-03 |
| Â | Â | xenobiotic metabolism | 9.4E-03 |
| Â | Â | response to xenobiotic stimulus | 1.0E-02 |
| Â | Â | keratinocyte differentiation | 1.0E-02 |
| Â | Â | endothelial cell differentiation | 1.0E-02 |
| Â | Â | UDP-glucose metabolism | 1.0E-02 |
| Â | Â | myoblast differentiation | 1.0E-02 |
| Â | Â | cell growth and/or maintenance | 1.1E-02 |
| Â | Â | G2/M transition of mitotic cell cycle | 1.4E-02 |
| Â | Â | cellular process | 1.4E-02 |
| Â | Â | cell organization and biogenesis | 1.4E-02 |
| Â | Â | lipid transport | 1.5E-02 |
| Â | Â | cysteine metabolism | 1.5E-02 |
| Â | Â | embryogenesis and morphogenesis | 2.3E-02 |
| Â | Â | synaptic transmission, cholinergic | 2.5E-02 |
| Â | Â | actin filament polymerization | 2.5E-02 |
| Â | Â | oncogenesis | 2.7E-02 |
| Â | Â | response to chemical substance | 2.9E-02 |
| Â | Â | electron transport | 2.9E-02 |
| Â | Â | regulation of cell migration | 3.0E-02 |
| Â | Â | glycosaminoglycan biosynthesis | 3.0E-02 |
| Â | Â | regulation of DNA replication | 3.5E-02 |
| Â | Â | N signaling pathway | 3.5E-02 |
| Â | Â | heavy metal sensitivity/resistance | 3.5E-02 |
| Â | Â | nerve-nerve synaptic transmission | 3.5E-02 |
| Â | Â | aminoglycan biosynthesis | 3.5E-02 |
| Â | Â | glutathione biosynthesis | 3.5E-02 |
| Â | Â | regulation of apoptosis | 4.0E-02 |
| Â | Â | glutathione metabolism | 4.0E-02 |
| Â | Â | nucleotide-sugar metabolism | 4.0E-02 |
| Â | Â | negative regulation of apoptosis | 4.5E-02 |
| Â | Â | anti-apoptosis | 4.5E-02 |
| Â | Â | carboxylic acid metabolism | 4.7E-02 |
| Â | Â | organic acid metabolism | 4.8E-02 |
| Â | Â | lipoprotein metabolism | 5.0E-02 |
| Â | Â | nitric oxide metabolism | 5.0E-02 |
| Â | Â | nitric oxide biosynthesis | 5.0E-02 |