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Table 5 Genes that were significantly altered by at least 1.4-fold in response to BaP in both MCF-7 and HepG2 cells

From: Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2

IMAGE Clone ID Gene Symbol Genbank Accession Number Gene Title Biological Process Direction of expression alteration2 Pearson correlation with DNA adducts
      MCF-7 HepG2 MCF-7 HepG2
1473304 AKR1C3 BQ939577 Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) cell proliferation; prostaglandin metabolism 0.261 -0.065
810724 IER3 BM994398 Immediate early response 3 anti-apoptosis; cell growth and/or maintenance; embryogenesis and morphogenesis; morphogenesis 0.192 0.805 1
789376 TXNRD1 NM_003330 Thioredoxin reductase 1 electron transport; heavy metal sensitivity/resistance; signal transduction 0.849 0.253
768443 MGST1 AK123482 Microsomal glutathione S-transferase 1 prostaglandin metabolism 0.599 0.815
196992 AKR1C1 AK095239 Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) xenobiotic metabolism 0.383 0.078
214006 HIST1H2BG NM_003518 Histone 1, H2bg nucleosome assembly; regulation of transcription\, DNA-dependent ↓↑ -0.780 -0.201
1842170 HIST1H4B BX102654 Histone 1, H4b nucleosome assembly; regulation of transcription\, DNA-dependent ↓↑ -0.620 -0.173
129467 HIST1H2BJ BF983642 Histone 1, H2bj nucleosome assembly; regulation of transcription\, DNA-dependent ↓↑ -0.709 -0.193
268891 HIST1H3D BQ051491 Histone 1, H3d embryogenesis and morphogenesis; nucleosome assembly ↓↑ -0.896 -0.214
263087 CRY1 AK125915 Cryptochrome 1 (photolyase-like) DNA repair; circadian rhythm; vision 0.805 0.215
140997 GDF15 BQ883534 Growth differentiation factor 15 signal transduction ↑↓ 0.940 0.716
273392 PIGF BM558246 Phosphatidylinositol glycan, class F GPI anchor biosynthesis 0.908 0.847
376772 RPS27L BC047648 Ribosomal protein S27-like cell proliferation; protein biosynthesis; signal transduction 0.944 0.380
1461138 HIST1H4C CD048335 Histone 1, H4c nucleosome assembly; regulation of transcription\, DNA-dependent ↓↑ -0.706 -0.156
205819 CPM NM_001874 Carboxypeptidase M aromatic compound metabolism; morphogenesis; proteolysis and peptidolysis 0.930 0.768
1673711 GOLGA1 U51587 Golgi autoantigen, golgin subfamily a, 1   ↑↓ -0.194 -0.206
166273 CDKN1A NM_078467 Cyclin-dependent kinase inhibitor 1A (p21, Cip1) cell cycle arrest; induction of apoptosis by intracellular signals; negative regulation of cell proliferation; oncogenesis; regulation of CDK activity 0.947 0.713
324356 NQO1 NM_000903 NAD(P)H dehydrogenase, quinone 1 electron transport; nitric oxide biosynthesis; response to toxin; synaptic transmission\, cholinergic; xenobiotic metabolism 0.884 -0.023
49442 TXNRD1 NM_003330 Thioredoxin reductase 1 electron transport; heavy metal sensitivity/resistance; signal transduction 0.866 0.003
233273 STOM NM_004099 Stomatin   0.925 0.886
25398 UNC84A BX640866 Unc-84 homolog A (C. elegans)   ↓↑ -0.662 -0.097
731750 TAF6L BC008785 TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa chromatin remodeling; regulation of transcription from Pol II promoter; transcription initiation ↓↑ -0.802 -0.210
381786 MAK NM_005906 Male germ cell-associated kinase protein amino acid phosphorylation; spermatogenesis 0.869 0.493
323511 C7ORF36 BX648555 Chromosome 7 open reading frame 36   0.917 0.567
760246 BLOC1S2 NM_001001342 Biogenesis of lysosome-related organelles complex-1, subunit 2   0.971 0.886
233279 SCD NM_005063 Stearoyl-CoA desaturase (delta-9-desaturase) fatty acid biosynthesis -0.372 -0.482
24032 CRADD AL832705 CASP2 and RIPK1 domain containing adaptor with death domain induction of apoptosis via death domain receptors; signal transduction 0.359 0.420
  1. 1Values in bold are significant Pearson correlations (p < 0.05).
  2. 2Genes with arrows in both directions represent those that were down-regulated at one time-point and then up-regulated at another or vice versa.